Antioxidants applied to fats to protect against rancidity do not cause immediate acute poisonings. However, such substances may accumulate in the human body due to their ability to dissolve in fats. Butylated hydro-xyanisole may undesirably influence their production process and cause cirrhosis of liver in experimental animals. Esters of gallate are known to inhibit enzymes, such as alcaline phosphatase, lipase, tetrapeptidase, cause degenerative changes in testicles, and in animal experiments, inhibit the growth of young animals.

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