Benzodiazepines Glucuronidation and Its Impact on Drug Screening

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Benzodiazepines (e.g., Valium (diazepam) and Librium (chlordiazepoxide)) are commonly prescribed minor tranquilizers, sedatives, and anticonvulsants. They are a large class of compounds and also undergo extensive metabolism, with glucuronida-tion often being the last step in the biotransformation. Most immunoassays for benzodiazepines involve antibodies raised against a common benzodiazepine metabolite, oxazepam. However, because most oxazepam excreted into the urine is actually oxazepam glucuronide, the immunoassay does not always perform well. The antibody has less reactivity with the oxazepam glucuronide, the actual metabolite present in urine. Some research has shown that pretreatment of the urine specimen with glucuronidase, which liberates the metabolite from binding with glucuronide, improves the sensitivity of the method.

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Do Not Panic

Do Not Panic

This guide Don't Panic has tips and additional information on what you should do when you are experiencing an anxiety or panic attack. With so much going on in the world today with taking care of your family, working full time, dealing with office politics and other things, you could experience a serious meltdown. All of these things could at one point cause you to stress out and snap.

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