Thyroid Carcinoma

Nuclear Grooves and Pseudoinclusions

Ptc Cytology

The presence of extensive nuclear grooves is a common finding in PTC, caused by an infolding of the nuclear membrane. Nuclear grooves are present in nearly all cases of PTC, but they may be sparse in up to 25 of cases. They are often parallel to the long axis of the oval nuclei, giving a coffee bean appearance (see Figure 9.5). Nuclear grooves alone are nonspecific and can be seen in a variety of neoplastic and non-neoplastic cells, including macrophages and benign follicular cells. However,...