Rsphrpilqa Glfanet Rsphrpilqa Glpahai Rsphrpilqa Glpaiiqt

L'LDVUE RSPHRPILQA GLPAJJlUT

IVAL TW AIL AW

GSNV GGDV GSDV GSDV

EFM RFV EFH ELLC

FIG. 3. Conserved sequence in the linker region between Ig-like domain II and III of FGFRs 13. The relative position of mutations occurring in FGFRs 1—3 clustered within three conserved amino acid residues are indicated. The conserved region thought to serve as a receptor dimerization domain is underlined (Wang et al 1997). Apert syndrome (AS), thanatophoric dysplasia (TD), PfeifTer syndrome (PS), non-syndromic craniosynostosis (NSC), immunoglobulin loops II and III (Igll, IgUI) are indicated. (Adapted from Ornitz 2000.)

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