John R Raymond Justin H Turner Andrew K Gelasco Henry B Ayiku Sonya D Coaxum John M Arthur and Maria N Garnovskaya

Summary

The purpose of this chapter is to summarize the main features of various signal transduction pathways utilized by the G protein-coupled 5-hydroxytryptamine (5-HT) receptors. Herein, we discuss major and secondary signals emanating from the major subtypes of 5-HT receptors (5-HTj, 5-HT2,5-HT4, 5-HT5, 5-HT6, and 5-HT7), as well as unique aspects of signaling for some of the subtypes. The 5-HT3 receptors, which are 5-HT gated ion channels, will not be discussed in this chapter. This chapter highlights the complexity of signaling from the diverse G protein-coupled 5-HT receptors and underscores the fundamental importance of understanding the nuances of the determinants of signaling specificity for these receptors.

Key Words: Guanosine-5'-0-(3-thio)triphosphate; phosphorylation; serotonin (5-hydroxytryptamine); G protein; kinase; receptor; calmodulin; phospholipase.

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