Evidence from in vitro and in vivo studies indicate that SNPs in the coding regions, mRNA editing (in the 5-HT2C receptor), and alternate mRNA splicing events occur in several human 5-HT receptors. These modification are associated with the symptoms of some physical diseases and psychiatric disturbances; they can alter the pharmacodynamics of antidepressants and antipsychotic drugs. Further insights into these cellular mechanisms are important from a public health perspective, as many antidepressants and antipsychotic medications are being used in the treatment of psychiatric disorders, either as a monotherapy or augmentation strategy (160-166).
Regarding posttranslational modifications, palmitoylation, glycosylation, and phosphorylation have been found in 5-HT receptors; each of these modifications has distinct roles in regulation of receptor functions. It is well known that phosphorylation, the modification of the serotonin receptors that has been studied most widely, plays an important role in receptor desensitization.
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