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Asthma and Allergy Foundation of America A

The fungi that are responsible for athlete's foot are called dermatophytes they live only on dead body tissue (hair, the outer layer of skin, and nails). The two dermatophytes responsible for athlete's foot are Trichophyton rubrum and T. mentagrophytes. The condition occurs both by direct and indirect contact it can be passed in locker rooms, showers, or shared towels or shoes.

Differential diagnosis of papulosquamous SCLE

Lupus Rash Forearms

The diseases, which we may consider in the differential diagnosis, are superficial gyrate erythema and tinea corporis. 3.4.2. Tinea corporis vs annular-polycyclic SCLE Dermatophytes are keratinophilic fungi that can produce different patterns of superficial infection of the glabrous skin. A non-inflammatory pattern, tinea circinata, presents with annular lesions with an active erythematous scaling border and central clearing. Contiguous annular lesions may merge to form polycyclic plaques that can be confused with SCLE, but tinea corporis is generally asymmetric and non-photodistributed. The diseases, which we may consider in differential diagnosis with the scaling pattern of early CCLE are actinic keratoses, seborrheic dermatitis, tinea faciei, psoriasis, and lichen ruber planus. Figure 18. Tinea faciei round, scaly plaque of dermatophyte infection on the face. Figure 18. Tinea faciei round, scaly plaque of dermatophyte infection on the face. 4.4.4. Tinea faciei vs early CCLE,...

Thallium in the human body

A fatal dose of thallium for an adult is around 800 mg, which is less than a quarter of a teaspoonful, and yet doses of 500 mg of thallium salts were prescribed medically as a pre-treatment for ringworm. J Only when all the hair had been removed was it thought possible to eradicate the fungus. Hair loss would begin after ten days or so, but such hair loss would today be taken as an indication that a person was suffering from near-lethal J Ringworm is highly contagious and is often transmitted through contact with farm animals like cows.

Description Of The Diseases

Tinea Capitis Description

Tinea cruris 3. Tinea barbae 5. Tinea capitis 6. Tinea corporis 2. Dermatophytosis Dermatophytoses are infections of keratinized structures, such as the nails, hair shafts, and stratum corneum of the skin, by organisms of three genera of fungi termed the dermatophytes. Although they are not part of the normal human skin flora, these organisms are particularly well adapted to infecting this location because they can use keratin as a source of nutrients unlike most other fungal pathogens. The different types of dermatophytosis are classified according to body site, using the word tinea, followed by a term for the particular body site. The major types of dermatophytosis and the most frequent organisms associated with them are listed in Table 41.1. The degree of inflammation produced in the lesions appears to depend primarily on the particular organism and perhaps also to some extent on the immunological competence of the patient. Tinea pedis (athlete's foot) is...

The medical uses and commercial abuses of thallium

Thallium salts were once part of the medical pharmacopoeia, and used to remove hair. This unusual effect of thallium was discovered by accident in the 1890s when thallium was tested on tuberculosis patients as a cure for night sweats. It didn't stop them having them, but their hair fell out. Dr R. J. Sabourand, the chief dermatologist at the St Louis Hospital in Paris, reported this side effect in 1898 for a while he used it specifically to remove body hair from those with ringworm but gave up using it because it was too toxic. Its use was revived in the early 1920s at a recommended dose of 8 mg kg bodyweight and it became the standard treatment for hair removal for 30 years, despite reports that around 40 of those given it experienced other side effects, generally very mild ones, although these were reported to disappear after three weeks. Another analysis of 500 patients, carried out by Drs Lourier and Zwitkis, was more reassuring in that no serious symptoms of thallium poisoning...

Thallium almost a perfect poison

Thallium, a metal, is probably largely unknown to the general public, but it has featured in a number of cases of homicidal, suicidal, and accidental poisoning. It has been used as a pesticide for killing insects and rats and has various uses in industry. At one time it was even used for removing unwanted hair and in the treatment of ringworm, for which a dose of 8 mg of thallium acetate per kilogram of body weight was given to children. This is dangerously close to the lethal dose of 12 mg per kilogram in adults. Needless to say, there have been a number of fatalities due to dosages having been incorrectly calculated, and some patients have suffered from its poisonous effects. The worst occurrence was in Granada, Spain in the 1930s when fourteen out of sixteen children who had been given the treatment died. The children had been given thallium acetate at a dose of 8 mg per kilogram of body weight, but the scales may have been inaccurate with the result that the dose was higher than...

Mercury and metabolism

The human body can tolerate quite large amounts of mercury, although if the total exceeds 4 g there is serious risk of death. (A fatal dose of methyl mercury is probably around 200 mg.) About one person in ten has a level of mercury in their body that would make them unsuitable as food for any cannibals who followed the nutritional guidelines regarding excess mercury levels in meat, that it should not exceed 0.05 ppm. Today most mercury comes from our food, but in former times the use of mercury in various household products such as floor polishes, laundry aids, and paint served to increase absorption of the metal especially as it can easily penetrate the skin. Absorption this way has led to severe poisoning, and sometimes children with ringworm died when they were treated with antifungal cream containing mercury. A 9-year-old girl died five days after a solution of mercury(II) chloride in alcohol had been applied to a patch of ringworm on her scalp.

Structure of the skin

In contrast to other fungal pathogens such as C albicans, Malassezia furfur, and Trichosporon beigelii, the dermatophytic fungi appear to be relatively incapable of causing disseminated disease, except for occasional local abscesses or granulomas in severely immunosuppressed patients. Thus, infections with dermatophytes are generally confined to the keratinized stratum corneum and the cutaneous appendages, such as the hair and nails. This phenomenon has been related to presence in the dermis of unsaturated transferrin, which may prevent growth of the organisms in the deeper layers of the skin by competition for iron. With various kinds of superficial fungal infections, there appears to be an inverse relationship between the degree of inflammation produced by a particular fungal pathogen and the chronicity of that infection. M. furfur and the anthropophilic dermatophytes, Trichophyton rubrum and Epidermophyton floccosum, generally produce little inflammation in their cutaneous lesions...

The Effects Of Poisoning By Organophosphate Insecticides

Despite the fact that some of the substances used as pesticides have unpleasant and potentially lethal effects on humans, they are of great importance both in economic and human health terms. Humans have been changing their environment for thousands of years and in many different ways. First, attempts to control what were seen as pests probably simply involved killing them by force (shooting foxes, for example), fire (burning fields after harvesting to kill both animal and plant pests), or using manual methods to remove plant pests such as weeds. Only relatively recently have we become more sophisticated. In the nineteenth century farmers applied chemicals such as Bordeaux mixture (copper sulphate) to plants to kill fungus. There is evidence that the antifungal properties of sulphur compounds were known in very early times, and people with fungus infections (ringworm, for example) were encouraged to bathe in sulphurous springs.


Terbinafine is the most active derivative of this class of antifungals. It has an excellent in vitro activity against the dermatophytes and other filamentous fungi, but its in vitro activity against the yeasts is controversial. It follows linear pharmacokinetics over a dose range of 125-750 mg drug concentrations of 0.5-2.7 g ml are detected 1 or 2h after a single oral dose. Terbinafine has replaced griseofulvin and keto-conazole for the treatment of onychomycosis and other infections caused by dermatophytes (oral and topical). It is also effective for the treatment of vulvo-vaginal candidiasis. It is usually well tolerated at oral doses of 250 and 500mg day and the side effects ( 10 ) are gastrointestinal and cutaneous. The

Amino acid analogs

RI 331, the azoxybacillins, and cispentacin are amino acid analogs with good in vitro antifungal activity against Aspergillus spp. and the dermatophytes (RI 331 and azoxybacillins) and also good in vivo activity (cispentacin). RI 331 and the azoxybacillins inhibit homoserine dehydrogenase and the biosynthesis of sulfur-containing amino acids, respectively. The derivative of histatin 5 called P-113 has antifungal in vitro activity against Candida species.


Note that HIV-infected children are subject to most of the opportunistic infections that can occur in adults. Some that are particularly notable in HIV-infected children are bacterial infections, can-didiasis and other fungal infections (oral candidia-sis, esophageal candidiasis, other fungal infections such as ringworm and athlete's foot), herpesvirus infections, measles virus, Mycobacterium avium complex, Pneumocystis carinii pneumonia, and tuberculosis. Diarrhea, lymphoid interstitial pneumonitis, and HIV encephalopathy are other important conditions in children with HIV disease.


Fungal infection The state or condition in which the body, or a part of it, is invaded by a pathogenic fungus. Terbinafine, an allylamine antifungal agent, has been shown to be effective in treating HIV-positive patients who have minor skin and nail fungal problems such as tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea circinata (ringworm, not a worm). other fungal infections that are considered opportunistic infections in HIVpositive people include candidiasis (Candida species), cryptococcosis, coccidioidomycosis (valley fever), and Aspergillus and histoplasmosis infections.

The Azoles

Voriconazole Synthesis

Thiabendazole was developed as an anthelmintic agent and has a limited activity against dermatophytes. It was also used in the past in the treatment of superficial yeast and dermatophytic infections. Thiabendazole has been used for aspergillosis and penicillosis in dogs. Clotrimazole is the first member of the triphenyl-methane series of clinical importance (Fig. 4.2C). It has good in vitro activity at very low concentrations against a large variety of fungi (yeasts and molds). However, hepatic enzymatic inactivation of this compound, after systemic administration, has limited its use to topical applications (1 cream, lotion, solution, tincture, and vaginal cream) for superficial mycoses (nail, scalp, and skin infections) caused by the dermatophytes and M. furfur, for initial and or mild oropharyngeal candidiasis (OPC 10-mg oral troche), and for the intravaginal therapy (single application of 500-mg intravaginal tablet) of vulvovaginal candidiasis. Other intravaginal drugs require...

Ritalin 433

Ringworm of the scalp (tinea capitis) involves scaly, temporary bad patches with dandruff-like white scales. The hair may be dull, and the infection may affect only one part of the scalp or may spread over the entire head. A severe case may include fever and swollen glands below the hairline. Ringworm of the nails causes thick, discolored, brittle, or chalky and friable nails. Ringworm of the body (tinea corporis) causes a flat and ring-shaped lesion the edge is red and may be dry and scaly, or moist and crusted. The center area is clear and appears normal. symptoms occur four to 10 days after contact. The rings can appear on face, legs, arms, or trunk. Ringworm of the foot appears as a scaling or cracking of the skin, especially between the toes.

Driving you hairless

William Crookes named thallium after the bright green colour it produced when its salts were put into a Bunsen burner flame. He compared the colour to that of a fresh green shoot, so he based its name on the Greek word for this, which is thallos. Thallium's deadly nature was not at first appreciated and it became part of the treatment for ringworm of the scalp, given in relatively large doses to children because it caused their hair to fall out, the better to treat the disease. Meanwhile others were using it to kill vermin, and always thallium brought tragedy in its wake. using it. The murder to be investigated was the death of Sir Henry Ancred who had been poisoned with thallium acetate which had been prescribed in the treatment of his granddaughter's ringworm. Marsh clearly had no knowledge of how thallium worked in that she imagined that those poisoned with it would drop dead in minutes. Would-be murderers seeking to emulate her villain would have been very puzzled when their...