Regulation of PSMA Expression by PSMA Promoter Enhancer

Psma Prostate Cancer

Prostate-specific membrane antigen has been shown to be increased severalfold in the expression in prostate cancer its expression is suppressed by androgen. Currently, two regulatory elements controlling PSMA expression have been characterized. The proximal Fig. 5. The regulation of PSMA in prostate cancer cells. Negative regulation by androgen receptor and positive regulation by Ca2+ is shown. Polyglutamated folates become enzymatically cleaved to deglu-tamated folates and glutamates. The...

Endocytic Function of PSMA

Psma Internalization

Prostate-specific membrane antigen, like other cell surface receptors, undergoes inter-nalization constitutively, and such spontaneous internalization is enhanced threefold in a dose-dependent manner by PSMA-specific monoclonal antibody J591 32 . It has been shown very clearly biochemically by using biotinylated cell surface PSMA followed by internalization of the protein , by immunofluorescence analysis or immunoelecton microscopy, that PSMA or the PSMA-antibody complex undergoes...