What does corpus callosum morphology tell us about callosal connections

The rather unsatisfactory reply is that callosal morphology is most likely a poor correlate of specific callosal connections for several reasons:

1. Interindividual comparison of callosal morphologies is reputably difficult even if obvious pitfalls are avoided (for discussion, see, e.g., Clarke et al., 1989). Identification of corresponding regions in different corpora callosal remains often hazardous.

2. A roughly ordered arrangement of axons within the corpus callosum according to their origin appears to be present in the genu and the splenium but not in the body.

3. The pathway taken by heterotopic callosal axons has not been investigated. The possibility that they travel in very different parts of the corpus callosum than the homotopic axons originating or terminating within the same region cannot be excluded.

4. Cortical regions that are known to be asymmetrical in the human might well receive (described here for the planum temporale) and give rise to widely heterotopic callosal connections.

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