Weeks

loss or gain. Pronounced neuroanatomical growth is observed during the 4-year interval (upper panel). This contrasts sharply with the negligible change detected over a 2-week time span (lower panel). (See Color Plate 4.)

Local Growth

Figure 5.6. Local analysis of callosal growth patterns using vector field operators. Vector field operators help to emphasize patterns of contractions and dilations, emphasizing their regional character. Here, the color code shows values of the local Jacobian of the warping field, which indicates local volume loss or gain. Pronounced neuroanatomical growth is observed during the 4-year interval (upper panel). This contrasts sharply with the negligible change detected over a 2-week time span (lower panel). (See Color Plate 4.)

cerebral volume, striking regional growth is detected throughout the callosum, with peak values occurring at the isthmus (the same area that was found to degenerate preferentially in our dementia studies (see Thompson et al., 1998b). This pronounced pattern of growth contrasts with the near-zero maps of change observed over a 2-week interval (Figure 5.6, lower panel).

Warping algorithms hold tremendous promise in representing, analyzing, and understanding the extremely complex dynamic processes that affect regional anatomy in the healthy and diseased brain. Only with a four-dimensional approach will patterns of callosal growth or degeneration be recorded in their full spatial and temporal complexity.

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