Insulin Receptor Number

Insulin receptor number has often been claimed as a potential indicator of Cr deficiency in humans (e.g., [81]). Despite the number of times this claim has been made, this claim is based on only a single study using only seven hypoglycemic subjects; IR number per cell (red blood cell) was increased significantly after 6 weeks but not 12 weeks of Cr treatment [82]. Other studies, including rat studies, have failed to observe any effects on IR number (e.g., [83] but see [84] on statistical analysis of the data).

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