We tested a total of 57 samples from 48 KD patients and found that only one of the 48 KD patients (2%) was positive for HCoV-NL63 RNA (Table 1). This patient met 4 of 5 classic clinical criteria for KD, but also exhibited symptoms of an upper respiratory tract infection, with cough and coryza which are rare symptoms for KD but common symptoms for HCoV-NL63 infection. Furthermore, although this patient responded with complete defervescence after administration of intravenous gamma globulin and aspirin that are common treatments for KD, his respiratory symptoms persisted. These results suggest that this KD patient was likely co-infected with HCoV-NL63.
Recent studies from Japan7 and the Centers for Disease Control and Prevention in the USA8 also report no association between infection with HCoV-NL63 and acute KD. Interestingly, a large study of pediatric patients in Europe found that HCoV-NL63 infection is associated with croup.9 Thus, although HCoV-NL63 is likely a common respiratory infection in children, we and others found no association with acute KD.
Was this article helpful?