Osterfield, M., M.W. Kirschner, and J.G. Flanagan, Graded positional information: interpretation for both fate and guidance. Cell, 2003. 113(4): p. 425-8.
 Panchision, D.M. and R.D. McKay, The control of neural stem cells by morphogenic signals. Curr Opin Genet Dev, 2002. 12(4): p. 478-87.
 Temple, S., The development of neural stem cells. Nature, 2001. 414(6859): p. 112-7.
 Gaiano, N. and G. Fishell, The role of notch in promoting glial and neural stem cell fates. Annu Rev Neurosci, 2002. 25: p. 471-90.
 Hitoshi, S., et al., Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev, 2002. 16(7): p. 846-58.
 Patten, I. and M. Placzek, The role of Sonic hedgehog in neural tube patterning. Cell Mol Life Sci, 2000. 57(12): p. 1695-708.
 Dupin, E., C. Real, and N. Ledouarin, The neural crest stem cells: control of neural crest cell fate and plasticity by endothelin-3. An Acad Bras Cienc, 2001. 73(4): p. 533-45.
 Knecht, A.K. and M. Bronner-Fraser, Induction of the neural crest: a multigene process. Nat Rev Genet, 2002. 3(6): p. 453-61.
Etchevers, H.C., G. Couly, and N.M. Le Douarin, Morphogenesis of the branchial vascular sector. Trends Cardiovasc Med, 2002. 12(7): p. 299-304.
Aybar, M.J. and R. Mayor, Early induction of neural crest cells: lessons learned from frog, fish and chick. Curr Opin Genet Dev, 2002. 12(4): p. 452-8.
Maschhoff, K.L. and H.S. Baldwin, Molecular determinants of neural crest migration. Am J Med Genet, 2000. 97(4): p. 280-8.
Shah, N.M., A.K. Groves, and D.J. Anderson, Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell, 1996. 85(3): p. 331-43. Carmeliet, P., Developmental biology. One cell, two fates. Nature, 2000. 408(6808): p. 43, 45. Mikkola, H.K. and S.H. Orkin, The search for the hemangioblast. J Hematother Stem Cell Res,
Carmeliet, P., Blood vessels and nerves: common signals, pathways and diseases. Nat Rev Genet,
Vogeli, K.M., et al., A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula. Nature, 2006. 443(7109): p. 337-9.
Rovainen, C.M., Labeling of developing vascular endothelium after injections of rhodamine-dextran into blastomeres ofXenopus laevis. J Exp Zool, 1991. 259(2): p. 209-21. Childs, S., et al., Patterning of angiogenesis in the zebrafish embryo. Development, 2002. 129(4): p. 973-82.
Brown, L.A., et al., Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos. Mech Dev, 2000. 90(2): p. 237-52.
Liao, W., et al., Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish. Development, 2000. 127(20): p. 4303-13.
Carmeliet, P., Developmental biology. Controlling the cellular brakes. Nature, 1999. 401(6754): p. 657-8.
Lyden, D., et al., Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature, 1999. 401(6754): p. 670-7.
Zhong, T.P., et al., Gridlock signalling pathway fashions the first embryonic artery. Nature, 2001. 414(6860): p. 216-20.
Fouquet, B., et al., Vessel patterning in the embryo of the zebrafish: guidance by notochord. Dev Biol, 1997. 183(1): p. 37-48.
Sumoy, L., et al., A role for notochord in axial vascular development revealed by analysis of phenotype and the expression of VEGR-2 in zebrafish flh and ntl mutant embryos. Mech Dev, 1997. 63(1): p. 15-27.
Ferrara, N., H.P. Gerber, and J. LeCouter, The biology of VEGF and its receptors. Nat Med, 2003. 9(6): p. 669-76.
Chen, J.N., et al., Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development, 1996. 123: p. 293-302.
Lawson, N.D., A.M. Vogel, and B.M. Weinstein, sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell, 2002. 3(1): p. 127-36.
Lawson, N.D. and B.M. Weinstein, In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev Biol, 2002. 248(2): p. 307-18.
Mukouyama, Y.S., et al., Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. Cell, 2002. 109(6): p. 693-705.
Visconti, R.P., C.D. Richardson, and T.N. Sato, Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF). Proc Natl Acad Sci USA, 2002. 99(12): p. 8219-24.
Stalmans, I., et al., Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest, 2002. 109(3): p. 327-36.
Lawson, N.D. and B.M. Weinstein, Arteries and veins: making a difference with zebrafish. Nat Rev Genet, 2002. 3(9): p. 674-82.
 Lawson, N.D., et al., Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development, 2001. 128(19): p. 3675-83.
 Lawson, N.D., et al., phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development. Genes Dev, 2003. 17(11): p. 1346-51.
 Kalimo, H., et al., CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia. Brain Pathol, 2002. 12(3): p. 371-84.
 You, L.R., et al., Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature, 2005. 435(7038): p. 98-104.
 Cleaver, O. and D.A. Melton, Endothelial signaling during development. Nat Med, 2003. 9(6): p. 661-8.
 Compernolle, V., et al., Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med,
 Eremina, V., et al., Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest, 2003. 111(5): p. 707-16.
 Gerber, H.P., et al., VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med, 1999. 5(6): p. 623-8.
 Huxlin, K.R., A.J. Sefton, and J.H. Furby, The origin and development of retinal astrocytes in the mouse. J Neurocytol, 1992. 21(7): p. 530-44.
 Zerlin, M. and J.E. Goldman, Interactions between glial progenitors and blood vessels during early postnatal corticogenesis: blood vessel contact represents an early stage of astrocyte differentiation. J Comp Neurol, 1997. 387(4): p. 537-46.
 Palmer, T.D., A.R. Willhoite, and F.H. Gage, Vascular niche for adult hippocampal neurogenesis. J Comp Neurol, 2000. 425(4): p. 479-94.
 Mi, H., H. Haeberle, and B.A. Barres, Induction of astrocyte differentiation by endothelial cells. J Neurosci, 2001. 21(5): p. 1538-47.
 Leventhal, C., et al., Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma. Mol Cell Neurosci, 1999. 13(6): p. 450-64.
 Bagnard, D., et al., Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor. J Neurosci, 2001. 21(10): p. 3332-41.
 Miao, H.Q., et al., Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165. J Cell Biol, 1999. 146(1): p. 233-42.
 Kokaia, Z. and O. Lindvall, Neurogenesis after ischaemic brain insults. Curr Opin Neurobiol,
 Monje, M.L. and T. Palmer, Radiation injury and neurogenesis. Curr Opin Neurol, 2003. 16(2): p. 129-34.
 Cooke, J.E. and C.B. Moens, Boundary formation in the hindbrain: Eph only it were simple. Trends Neurosci, 2002. 25(5): p. 260-7.
 Krull, C.E., Segmental organization of neural crest migration. Mech Dev, 2001. 105(1-2): p. 37-45.
 Tepass, U., D. Godt, and R. Winklbauer, Cell sorting in animal development: signalling and adhesive mechanisms in the formation of tissue boundaries. Curr Opin Genet Dev, 2002. 12(5): p. 572-82.
 Coulthard, M.G., et al., The role of the Eph-ephrin signalling system in the regulation of developmental patterning. Int J Dev Biol, 2002. 46(4): p. 375-84.
 Mellitzer, G., Q. Xu, and D.G. Wilkinson, Eph receptors and ephrins restrict cell intermingling and communication. Nature, 1999. 400(6739): p. 77-81.
 Xu, Q., et al., Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction ofgene expression in the Xenopus and zebrafish hindbrain. Development, 1995. 121(12): p. 4005-16.
 Cooke, J., et al., Eph signalling functions downstream of Val to regulate cell sorting and boundary formation in the caudal hindbrain. Development, 2001. 128(4): p. 571-80.
 Adams, R.H. and R. Klein, Eph receptors and ephrin ligands. essential mediators of vascular development. Trends Cardiovasc Med, 2000. 10(5): p. 183-8.
 Brantley, D.M., et al., Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene, 2002. 21(46): p. 7011-26.
 Gale, N.W., et al., Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev Biol, 2001. 230(2): p. 151-60.
 Shin, D., et al., Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev Biol, 2001. 230(2): p. 139-50.
 Wang, H.U., Z.F. Chen, and D.J. Anderson, Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell, 1998. 93(5): p. 741-53.
 Gerety, S.S., et al., Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell, 1999. 4(3): p. 403-14.
 Foo, S.S., et al., Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell, 2006. 124(1): p. 161-73.
 Carmeliet, P. and M. Tessier-Lavigne, Common mechanisms of nerve and blood vessel wiring. Nature, 2005. 436(7048): p. 193-200.
 Gerhardt, H., et al., VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol, 2003. 161(6): p. 1163-77.
 Autiero, M., et al., Role of neural guidance signals in blood vessel navigation. Cardiovasc Res, 2005. 65(3): p. 629-38.
 Honma, Y., et al., Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Neuron, 2002. 35(2): p. 267-82.
 Kuruvilla, R., et al., A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell, 2004. 118(2): p. 243-55.
 Dickson, B.J., Molecular mechanisms of axon guidance. Science, 2002. 298(5600): p. 1959-64.
 Huber, A.B., et al., Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance. Annu Rev Neurosci, 2003. 26: p. 509-63.
 Barallobre, M.J., et al., The Netrin family of guidance factors: emphasis on Netrin-1 signalling. Brain Res Brain Res Rev, 2005. 49(1): p. 22-47.
 Hong, K., et al., A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell, 1999. 97(7): p. 927-41.
 Keleman, K. and B.J. Dickson, Short- and long-range repulsion by the Drosophila Unc5 netrin receptor. Neuron, 2001. 32(4): p. 605-17.
 Fazeli, A., et al., Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature, 1997. 386(6627): p. 796-804.
 Serafini, T., et al., Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell, 1996. 87(6): p. 1001-14.
 Lu, X., et al., The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature, 2004. 432(7014): p. 179-86.
 Wilson, B.D., et al., Netrins promote developmental and therapeutic angiogenesis. Science, 2006. 313(5787): p. 640-4.
 Park, K.W., et al., The axonal attractant Netrin-1 is an angiogenic factor. Proc Natl Acad Sci USA, 2004. 101(46): p. 16210-5.
 Kidd, T., et al., Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Cell, 1998. 92(2): p. 205-15.
 Brose, K. and M. Tessier-Lavigne, Slit proteins: key regulators of axon guidance, axonal branching, and cell migration. Curr Opin Neurobiol, 2000. 10(1): p. 95-102.
 Kidd, T., K.S. Bland, and C.S. Goodman, Slit is the midline repellent for the robo receptor in Drosophila. Cell, 1999. 96(6): p. 785-94.
 Li, H.S., et al., Vertebrate slit, a secreted ligandfor the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell, 1999. 96(6): p. 807-18.
 Wang, K.H., et al., Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching. Cell, 1999. 96(6): p. 771-84.
 Plump, A.S., et al., Slitl and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Neuron, 2002. 33(2): p. 219-32.
 Long, H., et al., Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron, 2004. 42(2): p. 213-23.
 Sabatier, C., et al., The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell, 2004. 117(2): p. 157-69.
 Park, K.W., et al., Robo4 is a vascular-specific receptor that inhibits endothelial migration. Dev Biol, 2003. 261(1): p. 251-67.
 Huminiecki, L., et al., Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. Genomics, 2002. 79(4): p. 547-52.
 Bedell, V.M., et al., roundabout4 is essential for angiogenesis in vivo. Proc Natl Acad Sci USA, 2005. 102(18): p. 6373-8.
 Wang, B., et al., Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell, 2003. 4(1): p. 19-29.
 He, Z. and M. Tessier-Lavigne, Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell, 1997. 90(4): p. 739-51.
 Chen, H., et al., Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins. Neuron, 1998. 21(6): p. 1283-90.
 Takahashi, T., et al., Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors. Nat Neurosci, 1998. 1(6): p. 487-93.
 Fuh, G., K.C. Garcia, and A.M. de Vos, The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1. J Biol Chem, 2000. 275(35): p. 26690-5.
 Makinen, T., et al., Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1. J Biol Chem, 1999. 274(30): p. 21217-22.
 Migdal, M., et al., Neuropilin-1 is a placenta growth factor-2 receptor. J Biol Chem, 1998. 273(35): p. 22272-8.
 Gu, C., et al., Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165. J Biol Chem, 2002. 277(20): p. 18069-76.
 Gu, C., et al., Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell, 2003. 5(1): p. 45-57.
 Kruger, R.P., J. Aurandt, and K.L. Guan, Semaphorins command cells to move. Nat Rev Mol Cell Biol, 2005. 6(10): p. 789-800.
 Basile, J.R., et al., Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B. Cancer Res, 2004. 64(15): p. 5212-24.
 Weinstein, B.M., Vessels and nerves: marching to the same tune. Cell, 2005. 120(3): p. 299-302.
 Eichmann, A., et al., Guidance of vascular and neural network formation. Curr Opin Neurobiol, 2005. 15(1): p. 108-15.
 O'Leary, D.D. and D.G. Wilkinson, Eph receptors and ephrins in neural development. Curr Opin Neurobiol, 1999. 9(1): p. 65-73.
 Kullander, K. and R. Klein, Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol, 2002. 3(7): p. 475-86.
 Janes, P.W., et al., Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. Cell, 2005. 123(2): p. 291-304.
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