Pc3

Control

| Anterior LV wall Q Posterior LV wall

Figure 5. Molecular changes during dyssynchrony-induced preconditioning. In isolated rabbit hearts preconditioning is induced by 3 x 5 min pacing at the LV posterior wall. This kind of preconditioning reduced infarct size, after 30 min global ischemia, by half. In order to investigate molecular events, hearts were frozen immediately after the third period of pacing and 10 min later (see right upper panel, just before ischemia would have started in the full protocol, [93]). ERK 1/2 phosphorylation was increased selectively in the anterior wall, which showed stretching (yellow color in lower right panel). Ten min later, proBNP-mRNA was increased in the anterior and posterior wall [93]

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