Introduction

About two millennia ago, two major schools of thought arose in the ancient Greece, debating about the relative role of the brain or heart as a central source of life. The first school, headed by Plato, supported the concept that the brain harbored the soul, whereas Aristotle and his followers considered the heart and blood vessels of vital importance. As Aristotle stated: "the blood vessels system can be compared

Correspondence to: Peter Carmeliet, M.D., Ph.D., Professor of Medicine, Adjunct director, VIB Department of Transgene Technology and Gene Therapy, K.U. Leuven, Onderwijs en Narorsing O & N, 9e kerd, Campus Gasthuisberg, Herestraat 49, bus 912, 3000, LEUVEN, Tel: +32-16-34.57.74; Fax: +32-16-34.59.90, E-mail: [email protected]

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