Contents

Preface vii

List of Contributors ix

Part 1: The Clinical Challenge

1. Clinical Vascular Growth Factor Therapy for Neovascularization in Patients with Coronary Artery Disease 1

Jens Kastrup

2. The Strengths and Weaknesses of VEGF Adenovirus-Driven Angiogenesis 23 Petra Korpisalo, Tuomas T. Rissanen and Seppo Yla-Herttuala

3. Angiogenesis and Arteriogenesis in Diabetes Mellitus: Signal Transduction Defects as the Molecular Basis of Vascular Cell Dysfunction 33 Vadim Tchaikovski and Johannes Waltenberger

4. Endothelial Activation and Neointimal Hyperplasia:

A Double-Edged Sword 75

R. Khurana and M. Simons

Part 2: Novel Mechanical and Molecular Concepts

5. Pampering and Priming the Heart 85 M.J. Post, R.N.M. Cornelussen and F.W. Prinzen

6. Coronary Venous Retroinfusion: A Novel Venue of Regional

Induction of Neovascularization 109

Peter Boekstegers and Christian Kupatt

7. Integrative Pro-angiogenic Activation: HIF-1a Karen A. Vincent and Ralph A. Kelly

8. The Maturation of Vessels - A Limitation to Forced Neovascularization?

A. Banfi, P. Fueglistaler and R. Gianni-Barrera

9. Vascular and Neuronal Development: Intersecting Parallelisms and Crossroads

Serena Zacchigna, Carmen Ruiz de Almodovar, Peggy Lafuste and Peter Carmeliet

10. Cathelicidin Antimicrobial Peptides Modulate Angiogenesis Rembert Koczulla and Robert Bals

Contents 123

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