List of Contributors ix
Part 1: The Clinical Challenge
1. Clinical Vascular Growth Factor Therapy for Neovascularization in Patients with Coronary Artery Disease 1
2. The Strengths and Weaknesses of VEGF Adenovirus-Driven Angiogenesis 23 Petra Korpisalo, Tuomas T. Rissanen and Seppo Yla-Herttuala
3. Angiogenesis and Arteriogenesis in Diabetes Mellitus: Signal Transduction Defects as the Molecular Basis of Vascular Cell Dysfunction 33 Vadim Tchaikovski and Johannes Waltenberger
4. Endothelial Activation and Neointimal Hyperplasia:
A Double-Edged Sword 75
R. Khurana and M. Simons
Part 2: Novel Mechanical and Molecular Concepts
5. Pampering and Priming the Heart 85 M.J. Post, R.N.M. Cornelussen and F.W. Prinzen
6. Coronary Venous Retroinfusion: A Novel Venue of Regional
Induction of Neovascularization 109
Peter Boekstegers and Christian Kupatt
7. Integrative Pro-angiogenic Activation: HIF-1a Karen A. Vincent and Ralph A. Kelly
8. The Maturation of Vessels - A Limitation to Forced Neovascularization?
A. Banfi, P. Fueglistaler and R. Gianni-Barrera
9. Vascular and Neuronal Development: Intersecting Parallelisms and Crossroads
Serena Zacchigna, Carmen Ruiz de Almodovar, Peggy Lafuste and Peter Carmeliet
10. Cathelicidin Antimicrobial Peptides Modulate Angiogenesis Rembert Koczulla and Robert Bals
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All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.