CGRP See calcitonin generelated peptide

chaconine Toxic trisaccharide glycoalkaloid (alpha-chaconine) found in potatoes (Solanum tuberosum), where it is produced in increased amounts as a response to stress (and has insecticidal and fungicidal effect). Major alkaloid may be beta-chaconine, a disaccharide breakdown product of alpha-chaconine. Related to solanine. Imparts an unpleasantly bitter taste. Has cytotoxic effects that have been investigated for tumour therapy, and it has been reported that alpha-chaconine induces apoptosis of HT-29 cells through inhibition of ERK and, in turn, activation of caspase-3. Also has anticholine esterase activity. See solanidine.

chaeotropic Chaotropic An agent that causes chaos, usually in the sense of disrupting or denaturing macro-molecules. For example, iodide is often used in protein chemistry to break up and randomize micelles. In molecular biology, guanidium isothiocyanate is used to provide a denaturing environment in which RNA can be extracted intact without exposure to RNAases.

chaetoglobosins Chaetoglobosin J is a fungal metabolite related to cytochalasins that will inhibit elongation at the barbed end of an actin microfilament. Chaetoglobosin A is produced by Chaetomium globosum. Chaetoglobosin K is a plant growth inhibitor and toxin from the fungus Diplodia macrospora.

Chaetognatha Phylum of hermaphrodite marine coelo-mata with the body divided into three distinct regions: head, trunk and tail. Arrow-worms.

Chagas disease South American trypanosomiasis caused by Trypanosoma cruzi and transmitted by bloodsucking reduviid bugs such as Rhodnius.

chalaza 1. The basal part of a plant ovule where nucellus and integument are joined. 2. One of two spirally twisted cords of dense albumen connecting the yolk to the shell membrane in a bird's egg.

chalcone Intermediate in biosynthesis of flavanones, flavones and anthocyanidins by plants. Synthetic derivatives have been shown to have anti-inflammatory properties.

chalone Cell-released tissue-specific inhibitor of cell proliferation thought to be responsible for regulating the size of a population of cells. Their existence has been doubted but myostatin appears to be an example.

Chang liver cells Derived from non-malignant human tissue. Extensively used in virology and biochemistry. Cells are epithelial in morphology and grow to high density.

0 0

Post a comment