antitrypsin a-1-Antitrypsin; alpha-1-peptidase inhibitor; serpin A1 A major protein (54 kDa) of blood plasma (3 mg/ml in human), part of the a-globulin fraction and able to inhibit a wide spectrum of serine peptidases.
antitussive drug A cough suppressant. Most work by suppressing the cough reflex, rather than treating the cause of the cough.
antiviral drugs Drugs that inhibit viral infection. Two main categories have been developed so far; those which inhibit or interfere with the replication of viral nucleic acid (nucleoside analogues such as acyclovir and AZT), and those that interfere with virus-specific enzymes such as proteases (e.g. Saquinavir, Ritonavir, Indinavir) or neu-raminidases (e.g. Relenza, Tamiflu) which are important for processing of viral proteins to produce infective particles.
antizyme Repressor of ornithine decarboxylase (ODC). Antizyme (29 kDa) is a polyamine-inducible protein involved in feedback regulation of cellular polyamine levels. The N-terminus of antizyme is not required for the interaction with ODC but is necessary to induce its degradation. Antizyme can be induced by IL-1. The elaborate regulation of ODC activity in mammals still lacks a defined developmental role but an antizyme-like gene in Drosophila, gutfeeling (guf ), is required for proper development of the embryonic peripheral nervous system.
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