The menstruation of a sexually mature woman is a sign of a cyclic hormonal stimulation of the endometrium. It is well documented that the menstrual cycle influences many systemic disorders, such as asthma, porphyria, epilepsy, migraine, myasthenia gravis, and allergic rhinitis (1). Estrogen and progesterone, the two female sex hormones, can also lead to cycle-dependent variations in the activity of many skin disorders. Although detailed data on the cycle-associated hormonally mediated changes in the target organs, such as the uterus, vagina, cervix, and mammary glands, are available, little is known about the effects of the menstrual cycle on the skin (2). It is the goal of this chapter to provide an overview of the most important skin disorders with cycle-dependent variations.

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