TEWL was assessed in 58 women 18 to 35 years of age, with regular menstrual cycles (25 to 35 days) and a menstrual flow of five or less than five days. Exclusion criteria were the use of immunosuppressive drugs, chemotherapy, anti-inflammatories, antihistamines, or steroids; an active vulvar/vaginal infection; high blood pressure/cardiovascular disease, and pregnancy. Prior to treatment, the participants completed a medical questionnaire that included an atopic dermatitis self-assessment (Table 1) (17) and had their weight and height recorded. Participants received a set of standard cotton panties to wear during the study period and an oil-free, personal cleansing body wash to use in lieu of their normal cleansing product. Participants were asked to refrain from body cleansing within two hours of their clinical visit, from intercourse during the
Table 1 Relationship Between Participant Atopy Status and Vulvar Transepidermal Water Loss Parameter
Atopy Status (from Questionnaire)
Not atopic (Score < 6; n = 42) 15.5 + 1.0 24.2 + 1.8
Suspected atopy (Score 6-10; n = 5) 15.5 + 4.7 23.7 + 7.0
Atopic (Score > 10; n = 7) 18.5 + 3.1 28.6 + 5.7
Note: Participants were considered having atopy if their score was >10 or if participants had been diagnosed with atopy.
Abbreviations: SSWL, skin surface water loss; TEWL, transepidermal water loss; AUC, area under the curve; SEM, standard error of mean.
24 hours preceding their visit, and from drinking any caffeinated beverage on the day of their visit. We did not control all clothing worn, physical activity, or bathroom habits and practices.
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