Dermatitis Herpetiformis

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Although a report describing a premenstrual exacerbation of dermatitis herpeti-formis was published in 1906 (38), the medical literature contains few reports that refer to the influence of the menstrual cycle on the activity of this disease.

Clinically, it is difficult to distinguish the perimenstrual exacerbation of dermatitis herpetiformis from an autoimmune progesterone dermatitis. The diagnosis must be based on histopathology, direct immunofluorescence, and the lack of evidence for an autosensitization to progesterone (39).

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