Table 6. Marker antibodies mainly used for detection of cancers with cervical lymph node metastasis from cancers with unknown primary

Differentiation of the cancer

Cancer type and localization

Antibodies used


Upper aerodigestive tract lung esophagus

Cytokeratins CK8, 18, 19


Oropharynx, hypopharynx, larynx, esophagus, lung (non SCLC)

CK5, 6

Neuroendocrine cancers

Malignant paraganglioma, medullary thyroid cancer

Chromogranin A

Thyroid cancer (extrathyroidal)

Along ductus thyroglossus, upper mediastinum

Antithyroglobulin, antibodies


B and T

Common leukocyte antibodies

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