Laboratory

Laboratory findings in KD are not specific and are shared by other acute inflammatory febrile diseases. Early in the course of illness all the usual inflammatory parameters are increased, namely erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white blood cell (WBC), and ne-utrophil counts. Anemia may develop, particularly with more prolonged duration of active inflammation. Platelet (PTL) count is normal in the acute phase and markedly increases at the end of the second week reaching a value as high as 1,000,000/ mm3. Occasionally, a low platelet count may be detected in the acute phase as well as neutropenia. A moderate-high increase of serum concentration of liver enzymes may occur in the early stage in <40% of patients and mild hyperbilirubinemia in 10% (Knott et al., 2001).

Hypoalbuminemia is associated with more severe and prolonged acute disease. Urinalysis may show leukocytes and erythrocytes but no bacteria. Cerebrospinal fluid contains increased numbers of WBC, mainly lymphocytes, as expression of aseptic meningitis. Lipid profile alterations occur in the early phase including decreased levels of high-density lipoprotein (HDL) and cholesterol, and increased levels of triglycerides (Silva et al., 2001).

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