Main clinical cutaneous manifestations

Polyarteritis Nodosa

The spectrum of clinical vasculitis-related lesions is wide and includes erythema, purpura, papules, pustules, nodules, livedo, necrosis, ulcerations and or bullae. These different lesions are often associated, giving rise to a pleomorphic clinical picture, that is not specific to any of the systemic vasculitides, granulomatous or otherwise. Palpable purpura and petechiae are unquestionably the most frequent manifestations (Figs. 1 and 2). Lesions usually begin as tiny red macules that later...

Acute cutaneous lupus erythematosus

Lesions Face Aids

Acute cutaneous lupus erythematosus (ACLE) usually occurs in association with systemic manifestations preceding by weeks or months the onset of a multisystem disease (Watanabe and Tsuchida, 1995 Wysenbeek et al., 1992 Yung and Oakley, 2000). Sun exposure is a common exogenous factor to be capable of precipitating ACLE (Kuhn et al., 2001a Wysenbeek et al., 1989), and some patients even report an exacerbation of their systemic symptoms after exposure to sunlight. Furthermore, infections,...

Differential diagnosis of papulosquamous SCLE

Ring Lesion Central Clearing Scale

The diseases, which we may consider in the differential diagnosis with the papulosquamous pattern of SCLE are psoriasis and polymorphic light eruption. 3.3.1. Psoriasis vs papulosquamous SCLE Psoriasis is a chronic inflammatory disorder characterized by the presence of erythematous scaling plaques that in some cases can resemble SCLE. Differential features are a thicker scaling, with a silvery, micaceous appearance Fig. 9 and a different distribution of psoriasis plaques that predominantly...

Differential diagnosis of localized ACLE

Sle Generalized Rash

The diseases, which we may consider in the differential diagnosis with localized ACLE, are acne rosacea, contact dermatitis and photodermatitis, seborrheic dermatitis, dermatomyositis, erysipelas, and delusion of lupus. In its early stages, rosacea may present with a purely erythematous rash on the malar areas that can be very similar to ACLE. The rash may be triggered or aggravated by heat, cold, emotions, and by the ingestion of hot drinks, alcohol, and spicy foods. Differentiating early...

Diagnostic investigations

Raynauds Ulcers

The main and nearly universal symptom of SSc is skin sclerosis. Still, in some cases patients with characteristic serologic, visceral, and vascular changes lack skin thickening, which are then termed systemic scleroderma sine scleroderma. Several studies have suggested that the extent and progression of skin sclerosis is associated with mortality and internal organ involvement (Clements et al., 2000 Steen and Medsger, 2001). The most widely used assessment method for skin involvement is the...