Combination Therapy

In patients with combined dyslipidemia and low HDL-C levels, the combination of a statin with niacin is recommended. If a patient is not a candidate for niacin therapy, the group recommends substituting a fibrate. Also, the addition of fish oil in combination with a statin may be beneficial in patients with moderate hypertriglyceridemia.

Specific topics addressed in the 2003 Guidelines include the management of patients that are at high risk of CAD and are already at target for LDL-C (100 mg/dL), the management of patients who have combined dyslipidemia and low HDL-C levels, and the non-invasive assessment of CVD and other risk factors. Factors such as metabolic syndrome, apolipoprotein B, lipoprotein (a), homocysteine, and C-reactive protein are discussed as they relate to their influence on risk assessment.

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