trifluridine An antiviral used for topical treatment of infections caused by herpes simplex virus. In people infected with HIV, it has been used topically to treat skin, genital, and perianal HSV infections resistant to acyclovir. Trifluridine works by interfering with DNA synthesis in infected cells. It has been shown to be effective for treatment, but not prevention, of herpes virus infections. It is not effective against bacterial, fungal, or chlamydial infections. Available as a sterile solution for administration into the eyes. The most common effect of the optical solution is mild, transient burning when dropping it into the eye. Also called trifluo-rothymidine. (Trade name is Viroptic.)
triglyceride A combination of glycerol with three of five different fatty acids. These substances, triacylglycerols, are also called neutral fats. A large portion of the fatty substance in the blood is composed of triglycerides. Because these lipids are not soluble in water, they are transported in combination with proteins. About one or two grams of triglycerides per kilogram of body weight are ingested daily in the usual diet in the United States. In addition, they are produced in the liver from carbohydrates.
trimethoprim An antimicrobial agent that enhances the effect of sulfonamides and sulfones.
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