Dideoxycytidine ddC See zalcitabine dideoxyinosine ddl See didanosine

Didox A RIBONUCLEOTIDE REDUCTASE INHIBITOR, in the same drug class as hydroxyurea, under investigation for anti-HIV activity by Molecules for Health, Inc. It has shown promise in animal models of retrovirus illnesses when used alone or in combination with didanosine (ddl). Didox has been shown in studies to be much less toxic than hydroxyurea. It is also in trials for cancer treatment in Great Britain and is awaiting investigative new drug (IND) status with the NIH in the United States.

otics and other medications that destroy the body's "friendly" gastrointestinal bacteria also cause nutrient deficiencies. Gastrointestinal bacteria are necessary for the breakdown and absorption of certain food substances. Without them, foods cannot be digested properly and become useless to the body as a source of nutrients. Moreover, maldigested food may cause other problems, including diarrhea. Gastrointestinal bacteria also produce several different vitamins, including thiamin, riboflavin, niacin, pantothenic acid, vitamin B6, vitamin b12, folic acid, choline, biotin, and vitamin K.

People with HIV are usually advised to take a multiple vitamin-mineral supplement that supplies the basic level of nutrients most important to body function. Many nutritionists believe that additional supplements are necessary. Symptoms that may be related to nutrient deficiencies and may be reversible with appropriate supplementation include serious fatigue, memory loss or other cognitive dysfunction, skin problems, neuropathy, weight loss, loss of the senses of smell or taste, appetite loss, muscle pain or cramps, digestive problems, night blindness, canker sores, constipation, depression anxiety, menstrual cramps, and menopausal problems. Many other symptoms in people living with HIV may be related to nutrient deficiencies.

differential diagnosis Diagnosis based on comparison of symptoms of two or more similar diseases to determine the cause of illness.

Diflucan See fluconazole.

digital-anal sex Erotic stimulation of the anus with a finger or fingers.

diet supplements There are many different causes for nutrient deficiencies in people living with HIV: the high demand for antioxidants, the increased metabolism that begins in the earliest disease stages, malabsorption because of damage to the intestines, decreased intake of food because of mouth or throat problems, loss of appetite, loss of taste, fever, nausea, and vomiting. The resulting deficiencies are often of important nutrients critical for supporting immune function. The use of antibi

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