Although it is the case that only a few cell biology laboratories possess a calorimeter, it is to be hoped that this paper has demonstrated that thermobio-chemistry already has had a significant impact in several areas associated with cell physiology and particularly in the applied fields of biotechnology and pharmacology. The present author is convinced that its importance will increase dramatically in the coming post-genomic age, when everyone will be wishing to know the functions of all those myriads of expression systems and how they interact to give life. Calorimetry has the distinct advantage of a rigorous theoretical foundation in thermodynamics that will ensure its precise contribution to cell bi ol ogy and phys i ol ogy.

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