Gcl

Figure 4.4. Localization of glutamate transporter, GLAST, in the mouse retina. (A) and (B) are bright- and dark-field micrographs, respectively, showing GLAST mRNA localization by in situ hybridization using 35S-labeled riboprobes. Silver grains are localized to cell bodies in the inner nuclear and ganglion cell layers.

Figure 4.4. Localization of glutamate transporter, GLAST, in the mouse retina. (A) and (B) are bright- and dark-field micrographs, respectively, showing GLAST mRNA localization by in situ hybridization using 35S-labeled riboprobes. Silver grains are localized to cell bodies in the inner nuclear and ganglion cell layers.

elevated extracellular glutamate, and neurodegenerative changes characteristic of excitotoxicity. These observations suggest that glutamate transport by Müller cells may play an important role in modulating synaptic signaling in the retina as well as serving to protect the retina from chronic glutamate neurotoxicity.

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