References

Alms GR, Sanz P, Carlson M and Haystead TA (1999) Reglp targets protein phosphatase 1 to dephosphorylate hexokinase II in Saccharomyces cerevisiae: characterizing the effects of a phosphatase subunit on the yeast proteome. Embo J 18, 4157-4168.

Anderson RG and Jacobson K (2002) A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science 296,1821-1825.

Arnoult C, Cardullo RA, Lemos JR and Florman HM (1996) Activation of mouse sperm T-type Ca2+ channels by adhesion to the egg zona pellucida. Proc Natl Acad Sci USA 93, 13004-13009.

Arnoult C, Kazam IG, Visconti PE, Kopf GS, Villaz M and Florman HM (1999) Control of the low voltage-activated calcium channel of mouse sperm by egg ZP3 and by membrane hyper-polarization during capacitation. Proc Natl Acad Sci USA 96, 6757-6762.

Ashworth PJ, Harrison RA, Miller NG, Plummer JM and Watson PF (1995) Flow cytometric detection of bicarbonate-induced changes in lectin binding in boar and ram sperm populations. Mol Reprod Dev 40,164-176.

Asquith KL, Baleato RM, McLaughlin EA, Nixon B and Aitken RJ (2004) Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition. J Cell Sci 117, 3645-3657.

Austin CR (1951) Observations on the penetration of the sperm in the mammalian egg. Aust J Sci Res (B)4, 581-596.

Babcock DF (1983) Examination of the intracellular ionic environment and of ionophore action by null point measurements employing the fluorescein chromophore. J Biol Chem 258, 6380-6389.

Bailey JL and Storey BT (1994) Calcium influx into mouse spermatozoa activated by solubilized mouse zona pellucida, monitored with the calcium fluorescent indicator, fluo-3. Inhibition of the influx by three inhibitors of the zona pellucida induced acrosome reaction: tyrphostin A48, pertussis toxin, and 3-quinuclidinyl benzilate. Mol Reprod Dev 39,297-308.

Baker MA, Hetherington L, Ecroyd H, Roman SD and Aitken RJ (2004) Analysis of the mechanism by which calcium negatively regulates the tyrosine phosphorylation cascade associated with sperm capacitation. J Cell Sci 117,211-222.

Balasubramanian K and Schroit AJ (2003) Aminophospholipid asymmetry: a matter of life and death. Annu Rev Physiol 65, 701-734.

Baldi E, Luconi M, Bonaccorsi L, Muratori M and Forti G (2000) Intracellular events and signaling pathways involved in sperm acquisition of fertilizing capacity and acrosome reaction. Front Biosci 5,E110-E123.

Baxendale RW and Fraser LR (2003) Evidence for multiple distinctly localized adenylyl cyclase isoforms in mammalian spermatozoa. Mol Reprod Dev 66,181-189.

Berruti G (1994) Biochemical characterization of the boar sperm 42 kilodalton protein tyrosine kinase: its potential for tyrosine as well as serine phosphorylation towards microtubule-associated protein 2 and histone H 2B. Mol Reprod Dev 38, 386-392.

Bevers EM, Comfurius P, Dekkers DW, Harmsma M and Zwaal RF (1998) Transmembrane phospholipid distribution in blood cells: control mechanisms and pathophysiological significance. Biol Chem 379, 973-986.

Blomberg A (1997) Osmoresponsive proteins and functional assessment strategies in Saccharomyces cerevisiae. Electrophoresis 18,1429-1440.

Boatman DE and Robbins RS (1991) Bicarbonate: carbon-dioxide regulation of sperm capacitation, hyperactivated motility, and acrosome reactions. Biol Reprod 44, 806-813.

Brooks DE (1983) Epididymal functions and their hormonal regulation. Aust J Biol Sci 36, 205-221.

Brown DA and London E (1998) Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 14, 111-136.

Brown DA and London E (2000) Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J Biol Chem 275, 17221-17224.

Buck J, Sinclair ML, Schapal L, Cann MJ and Levin LR (1999) Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Proc Natl Acad Sci USA 96, 79-84.

Bunch DO, Welch JE, Magyar PL, Eddy EM and O'Brien DA (1998) Glyceraldehyde 3-phosphate dehydrogenase-S protein distribution during mouse spermatogenesis. Biol Reprod 58, 834-841.

Burks DJ, Carballada R, Moore HD and Saling PM (1995) Interaction of a tyrosine kinase from human sperm with the zona pellucida at fertilization. Science 269, 83-86.

Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL and Babcock DF (2003) CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci USA 100,14864-14868.

Carrera A, Moos J, Ning XP, Gerton GL, Tesarik J, Kopf GS and Moss SB (1996) Regulation of protein tyrosine phosphorylation in human sperm by a calcium/calmodulin-dependent mechanism: identification of a kinase anchor proteins as major substrates for tyrosine phosphorylation. Dev Biol 180, 284-296.

Chang MC (1951) Fertilizing capacity of spermatozoa deposited into the fallopian tubes. Nature 168, 697-698.

Chaudhry PS, Nanez R and Casillas ER (1991a) Purification and characterization of polyamine-stimulated protein kinase (casein kinase II) from bovine spermatozoa. Arch Biochem Biophys 288, 337-342.

Chaudhry PS, Newcomer PA and Casillas ER (1991b) Casein kinase I in bovine sperm: purification and characterization. Biochem Biophys Res Commun 179, 592-598.

Chen Y, Cann MJ, Litvin TN, Iourgenko V, Sinclair ML, Levin LR and Buck J (2000) Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science 289, 625-628.

Choi YH and Toyoda Y (1998) Cyclodextrin removes cholesterol from mouse sperm and induces capacitation in a protein-free medium. Biol Reprod 59, 1328-1333.

Cohen-Dayag A and Eisenbach M (1994) Potential assays for sperm capacitation in mammals. Am J Physiol 267, C1167-C1176.

Cornelius F (1995) Phosphorylation/dephosphorylation of reconstituted shark Na + , K( + )-ATPase: one phosphorylation site per alpha beta protomer. Biochim Biophys Acta 1235, 197-204.

Cross NL (1996) Effect of cholesterol and other sterols on human sperm acrosomal responsiveness. Mol Reprod Dev 45, 212-217.

Cross NL (1998) Role of cholesterol in sperm capacitation. Biol Reprod 59, 7-11.

Cross NL (1999) Effect of methyl-beta-cyclodextrin on the acrosomal responsiveness of human sperm. Mol Reprod Dev 53, 92-98.

Cross NL (2004) Reorganization of lipid rafts during capacitation of human sperm. Biol Reprod 71,1367-1373.

Cross NL and Overstreet JW (1987) Glycoconjugates of the human sperm surface: distribution and alterations that accompany capacitation in vitro. Gamete Res 16, 23-35.

Darszon A, Beltran C, Felix R, Nishigaki T and Trevino CL (2001) Ion transport in sperm signaling. Dev Biol 240,1-14.

Davis BK (1981) Timing of fertilization in mammals: sperm cholesterol/phospholipid ratio as a determinant of the capacitation interval. Proc Natl Acad Sci USA 78, 7560-7564.

Davis BK, Byrne R and Hungund B (1979) Studies on the mechanism of capacitation. II. Evidence for lipid transfer between plasma membrane of rat sperm and serum albumin during capacitation in vitro. Biochim Biophys Acta 558,257-266.

Davis BK, Byrne R and Bedigian K (1980) Studies on the mechanism of capacitation: albuminmediated changes in plasma membrane lipids during in vitro incubation of rat sperm cells. Proc Natl Acad Sci USA 77,1546-1550.

de Lamirande E, Leclerc P and Gagnon C (1997) Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization. Mol Human Reprod 3,175-194.

Demarco IA, Espinosa F, Edwards J, Sosnik J, De La Vega-Beltran JL, Hockensmith JW, Kopf GS, Darszon A and Visconti PE (2003) Involvement of a Na+/HCO-3 cotransporter in mouse sperm capacitation. J Biol Chem 278, 7001-7009.

Devi KU, Jha K and Shivaji S (1999) Plasma membrane-associated protein tyrosine phosphatase activity in hamster spermatozoa. Mol Reprod Dev 53, 42-50.

de Vries KJ, Wiedmer T, Sims PJ and Gadella BM (2003) Caspase-independent exposure of aminophospholipids and tyrosine phosphorylation in bicarbonate responsive human sperm cells. Biol Reprod 68, 2122-2134.

Eddy EM and O'Brien DA (1994) The spermatozoon. In: The Physiology of Reproduction, Vol. 1, eds E Knobil and JD Neill, New York: Raven Press, pp. 29-77.

Edidin M (2001) Membrane cholesterol, protein phosphorylation, and lipid rafts. Sci STKE 2001, PE1.

Espinosa F, Lopez-Gonzalez I, Munoz-Garay C, Felix R, De la Vega-Beltran JL, Kopf GS, Visconti PE and Darszon A (2000) Dual regulation of the T-type Ca(2 + ) current by serum albumin and beta-estradiol in mammalian spermatogenic cells. FEBS Lett 475,251-526.

Esposito G, Jaiswal BS, Xie F et al. (2004) Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci USA 101, 2993-2998.

Ficarro S, Chertihin O, Westbrook VA et al. (2003) Phosphoproteome analysis of human sperm. Evidence of tyrosine phosphorylation of AKAP 3 and valosin containing protein/P97 during capacitation. J Biol Chem 278, 11579-11589.

Flesch FM and Gadella BM (2000) Dynamics of the mammalian sperm plasma membrane in the process of fertilization. Biochim Biophys Acta 1469,197-235.

Flesch FM, Brouwers JF, Nievelstein PF, Verkleij AJ, van Golde LM, Colenbrander B and Gadella BM (2001a). Bicarbonate stimulated phospholipid scrambling induces cholesterol redistribution and enables cholesterol depletion in the sperm plasma membrane. J Cell Sci 114,3543-3555.

Flesch FM, Wijnand E, van de Lest CH, Colenbrander B, van Golde LM and Gadella BM (2001b). Capacitation dependent activation of tyrosine phosphorylation generates two sperm head plasma membrane proteins with high primary binding affinity for the zona pellucida. Mol Reprod Dev 60,107-115.

Florman HM and Babcock DF (1991) Progress towards understanding the molecular basis of capacitation. In: Chemistry of Fertilization. CRC: Uniscience, pp. 105-132.

Florman HM, Tombes RM, First NL and Babcock DF (1989) An adhesion-associated agonist from the zona pellucida activates G protein-promoted elevations of internal Ca2+ and pH that mediate mammalian sperm acrosomal exocytosis. Dev Biol 135, 133-146.

Florman HM, Arnoult C, Kazam IG, Li C and O'Toole CM (1998) A perspective on the control of mammalian fertilization by egg-activated ion channels in sperm: a tale of two channels. Biol Reprod 59, 12-16.

Fraser LR (1977) Differing requirements for capacitation in vitro of mouse spermatozoa from two strains. J Reprod Fertil 49, 83-87.

Fukami K, Yoshida M, Inoue T, Kurokawa M, Fissore RA, Yoshida N, Mikoshiba K and Takenawa T (2003) Phospholipase Cdelta4 is required for Ca2+ mobilization essential for acrosome reaction in sperm. J Cell Biol 161, 79-88.

Gadella BM and Harrison RA (2000) The capacitating agent bicarbonate induces protein kinase A-dependent changes in phospholipid transbilayer behavior in the sperm plasma membrane. Development 127,2407-2420.

Gadella BM and Harrison RA (2002) Capacitation induces cyclic adenosine 3',5'-monophosphate-dependent, but apoptosis-unrelated, exposure of aminophospholipids at the apical head plasma membrane of boar sperm cells. Biol Reprod 67, 340-350.

Gadella BM and Van Gestel RA (2004) Bicarbonate and its role in mammalian sperm function. Anim Reprod Sci 82-83, 307-319.

Gadella BM, Gadella Jr TW, Colenbrander B, van Golde LM and Lopes-Cardozo M (1994) Visualization and quantification of glycolipid polarity dynamics in the plasma membrane of the mammalian spermatozoon. J Cell Sci 107, 2151-2163.

Gadella BM, Lopes-Cardozo M, van Golde LM, Colenbrander B and Gadella Jr TW (1995) Glycolipid migration from the apical to the equatorial subdomains of the sperm head plasma membrane precedes the acrosome reaction. Evidence for a primary capacitation event in boar spermatozoa. J Cell Sci 108, 935-946.

Gadella BM, Miller NG, Colenbrander B, van Golde LM and Harrison RA (1999) Flow cytometric detection of transbilayer movement of fluorescent phospholipid analogues across the boar sperm plasma membrane: elimination of labeling artifacts. Mol Reprod Dev 53, 108-125.

Galantino-Homer HL, Visconti PE and Kopf GS (1997) Regulation of protein tyrosine phosphorylation during bovine sperm capacitation by a cyclic adenosine 3'5'-monophosphate-dependent pathway. Biol Reprod 56, 707-719.

Garbers DL, Tubb DJ and Hyne RV (1982) A requirement of bicarbonate for Ca2 + -induced elevations of cyclic AMP in guinea pig spermatozoa. J Biol Chem 257, 8980-8984.

Garty NB, Galiani D, Aharonheim A, Ho YK, Phillips DM, Dekel N and Salomon Y (1988) G-proteins in mammalian gametes: an immunocytochemical study. J Cell Sci 91,21-31.

Gatti JL, Billard R and Christen R (1990) Ionic regulation of the plasma membrane potential of rainbow trout (Salmo gairdneri) spermatozoa: role in the initiation of sperm motility. J Cell Physiol 143, 546-554.

Gillan L, Evans G and Maxwell WM (2005) Flow cytometric evaluation of sperm parameters in relation to fertility potential. Theriogenology 63, 445-457.

Go KJ and Wolf DP (1985) Albumin-mediated changes in sperm sterol content during capacitation. Biol Reprod 32, 145-153.

Gorg A, Postel W and Gunther S (1988) The current state of two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis 9, 531-546.

Green CE and Watson PF (2001) Comparison of the capacitation-like state of cooled boar spermatozoa with true capacitation. Reproduction 122, 889-898.

Gross MK, Toscano DG and Toscano Jr WA (1987) Calmodulin-mediated adenylate cyclase from mammalian sperm. J Biol Chem 262, 8672-8676.

Hanoune J and Defer N (2001) Regulation and role of adenylyl cyclase isoforms. Annu Rev Pharmacol Toxicol 41,145-174.

Hao Z, Jha KN, Kim YH et al. (2004). Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. Mol Human Reprod 10, 433-444.

Harrison RA (1996) Capacitation mechanisms, and the role of capacitation as seen in eutherian mammals. Reprod Fertil Dev 8, 581-594.

Harrison RA (2004) Rapid PKA-catalysed phosphorylation of boar sperm proteins induced by the capacitating agent bicarbonate. Mol Reprod Dev 67, 337-352.

Harrison RA and Gadella BM (2005) Bicarbonate-induced membrane processing in sperm capacitation. Theriogenology 63, 342-351.

Harrison RA and Miller NG (2000) cAMP-dependent protein kinase control of plasma membrane lipid architecture in boar sperm. Mol Reprod Dev 55, 220-228.

Harrison RA, Ashworth PJ and Miller NG (1996) Bicarbonate/CO2, an effector of capacitation, induces a rapid and reversible change in the lipid architecture of boar sperm plasma membranes. Mol Reprod Dev 45, 378-391.

Hoshi K, Aita T, Yanagida K, Yoshimatsu N and Sato A (1990) Variation in the cholesterol/ phospholipid ratio in human spermatozoa and its relationship with capacitation. Human Reprod 5, 71-74.

Huo LJ and Yang ZM (2000) Effects of platelet activating factor on capacitation and acrosome reaction in mouse spermatozoa. Mol Reprod Dev 56, 436-440.

Jahn R and Sudhof TC (1999) Membrane fusion and exocytosis. Ann Rev Biochem 68, 863-911.

Kabouridis PS, Magee AI and Ley C (1997) S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. Embo J 16, 4983-4998.

Kalab P, Peknicova J, Geussova G and Moos J (1998) Regulation of protein tyrosine phosphorylation in boar sperm through a cAMP-dependent pathway. Mol Reprod Dev 51, 304-314.

Kaldis P, Stolz M, Wyss M, Zanolla E, Rothen-Rutishauser B, Vorherr T and Wallimann T (1996) Identification of two distinctly localized mitochondrial creatine kinase isoenzymes in spermatozoa. J Cell Sci 109, 2079-2088.

Killian GJ (2004) Evidence for the role of oviduct secretions in sperm function, fertilization and embryo development. Anim Reprod Sci 82-83, 141-153.

Kusumi A, Koyama-Honda I and Suzuki K (2004) Molecular dynamics and interactions for creation of stimulation-induced stabilized rafts from small unstable steady-state rafts. Traffic 5,213-220.

Laflamme J, Akoum A and Leclerc P (2005) Induction of human sperm capacitation and protein tyrosine phosphorylation by endometrial cells and interleukin-6. Mol Human Reprod 11, 141-150.

Langlais J and Roberts JD (1985) A molecular membrane model of sperm capacitation and the acrosome reaction of mammalian spermatozoa. Gamete Res 12, 183-224.

Leclerc P and Goupil S (2002) Regulation of the human sperm tyrosine kinase c-yes. Activation by cyclic adenosine 3',5'-monophosphate and inhibition by Ca(2 + ). Biol Reprod 67, 301-307.

Leclerc P, de Lamirande E and Gagnon C (1996) Cyclic adenosine 3',5'-monophosphate-dependent regulation of protein tyrosine phosphorylation in relation to human sperm capacitation and motility. Biol Reprod 55, 684-692.

Lee MA and Storey BT (1986) Bicarbonate is essential for fertilization of mouse eggs: mouse sperm require it to undergo the acrosome reaction. Biol Reprod 34, 349-356.

Lewis TS, Hunt JB, Aveline LD et al. (2000) Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry. Mol Cell 6, 1343-1354.

Lievano A, Santi CM, Serrano CJ, Trevino CL, Bellve AR, Hernandez-Cruz A and Darszon A (1996) T-type Ca2+ channels and alpha1E expression in spermatogenic cells, and their possible relevance to the sperm acrosome reaction. FEBS Lett 388,150-154.

Luconi M, Krausz C, Forti G and Baldi E (1996) Extracellular calcium negatively modulates tyro-sine phosphorylation and tyrosine kinase activity during capacitation of human spermatozoa. Biol Reprod 55,207-216.

Luconi M, Barni T, Vannelli et al. (1998) Extracellular signal-regulated kinases modulate capacitation of human spermatozoa. Biol Reprod 58,1476-1489.

Mahi CA and Yanagimachi R (1976) Maturation and sperm penetration of canine ovarian oocytes in vitro. J Exp Zool 196,189-196.

Manning G, Plowman GD, Hunter T and Sudarsanam S (2002) Evolution of protein kinase signaling from yeast to man. Trend Biochem Sci 27, 514-520.

Marin-Briggiler CI, Tezon JG, Miranda PV and Vazquez-Levine MH (2002) Effect of incubating human sperm at room temperature on capacitation-related events. Fertil Steril 77, 252-259.

Marin S, Chiang K, Bassilian S et al. (2003) Metabolic strategy of boar spermatozoa revealed by a metabolomic characterization. FEBS Lett 554, 342-346.

Mayorga LS, Beron W, Sarrouf MN, Colombo MI, Creutz C and Stahl PD (1994) Calcium-dependent fusion among endosomes. J Biol Chem 269, 30927-30934.

McCauley TC, Buhi WC, Wu GM, Mao J, Caamano JN, Didion BA and Day BN (2003) Oviduct-specific glycoprotein modulates sperm-zona binding and improves efficiency of porcine fertilization in vitro. Biol Reprod 69, 828-834.

Mehats C, Andersen CB, Filopanti M, Jin SL and Conti M (2002) Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling. Trend Endocrinol Metab 13,29-35.

Michaut M, Tomes CN, De Blass G, Yunes R and Mayorga LS (2000) Calcium-triggered acroso-mal exocytosis in human spermatozoa requires the coordinated activation of rab3A and N-ethylmaleimide-sensitive factor. Proc Nat Acad Sci USA 97, 9996-10001.

Miki K, Qu W, Goulding EH, Willis WD et al. (2004) Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility. Proc Natl Acad Sci USA 101,16501-16506.

Mitra K and Shivaji S (2004) Novel tyrosine-phosphorylated post-pyruvate metabolic enzyme, dihydrolipoamide dehydrogenase, involved in capacitation of hamster spermatozoa. Biol Reprod 70, 887-899.

Morisawa M and Suzuki K (1980) Osmolality and potassium ion: their roles in initiation of sperm motility in teleosts. Science 210, 1145-1147.

Mukai C and Okuno M (2004) Glycolysis plays a major role for adenosine triphosphate supplementation in mouse sperm flagellar movement. Biol Reprod 71, 540-547.

Munoz-Garay C, De la Vega-Beltran JL, Delgado R, Labarca P, Felix R and Darszon A (2001) Inwardly rectifying K(+) channels in spermatogenic cells: functional expression and implication in sperm capacitation. Dev Biol 234, 261-274.

Neill JM and Olds-Clarke P (1987) A computer-assisted assay for mouse sperm hyperactivation demonstrates that bicarbonate but not bovine serum albumin is required. Gamete Res 18, 121-140.

Nolan JP, Magargee SF, Posner RG and Hammerstedt RH (1995) Flow cytometric analysis of transmembrane phospholipid movement in bull sperm. Biochemistry 34, 3907-3915.

Nolan MA, Babcock DF, Wennemuth G, Brown W, Burton KA and McKnight GS (2004) Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility. Proc Natl Acad Sci USA 101,13483-13488.

O'Farrell PH (1975) High resolution two-dimensional electrophoresis of proteins. J Biol Chem 250,4007-4021.

Okamura N and Sugita Y (1983) Activation of spermatozoan adenylate cyclase by a low molecular weight factor in porcine seminal plasma. J Biol Chem 258,13056-13062.

Okamura N, Tajima Y, Soejima A, Masuda H and Sugita Y (1985) Sodium bicarbonate in seminal plasma stimulates the motility of mammalian spermatozoa through direct activation of adenylate cyclase. J Biol Chem 260, 9699-9705.

Osheroff JE, Visconti PE, Valenzuela JP, Travis AJ, Alvarez J and Kopf GS (1999) Regulation of human sperm capacitation by a cholesterol efflux-stimulated signal transduction pathway leading to protein kinase A-mediated up-regulation of protein tyrosine phosphorylation. Mol Human Reprod 5, 1017-1026.

Overstreet JW and Cooper GW (1978) Sperm transport in the reproductive tract of the female rabbit: I. The rapid transit phase of transport. Biol Reprod 19, 101-114.

Parrish JJ, Susko-Parrish JL and First NL (1989) Capacitation of bovine sperm by heparin: inhibitory effect of glucose and role of intracellular pH. Biol Reprod 41, 683-699.

Pommer AC, Rutllant J and Meyers SA (2003) Phosphorylation of protein tyrosine residues in fresh and cryopreserved stallion spermatozoa under capacitating conditions. Biol Reprod 68, 1208-1214.

Pomorski T, Herrmann A, Zimmermann B, Zachowski A and Muller P (1995) An improved assay for measuring the transverse redistribution of fluorescent phospholipids in plasma membranes. Chem Phys Lipids 77, 139-146.

Quill TA, Sugden SA, Rossi KL, Doolittle LK, Hammer RE and Garbers DL (2003) Hyper-activated sperm motility driven by CatSper2 is required for fertilization. Proc Natl Acad Sci USA 100,14869-14874.

Rajendran L and Simons K (2005) Lipid rafts and membrane dynamics. J Cell Sci 118,1099-1102.

Ramalho-Santos J, Moreno RD, Sutovsky P et al. (2000) SNARE's in mammalian sperm: possible implications for fertilization. Dev Biol 223, 54-69.

Rathi R, Colenbrander B, Bevers MM and Gadella BM (2001) Evaluation of in vitro capacitation of stallion spermatozoa. Biol Reprod 65, 462-470.

Rathi R, Colenbrander B, Stout TA, Bevers MM and Gadella BM (2003) Progesterone induces acrosome reaction in stallion spermatozoa via a protein tyrosine kinase dependent pathway. Mol Reprod Dev 64,120-128.

Ren D, Navarro B, Perez G et al. (2001) A sperm ion channel required for sperm motility and male fertility. Nature 413, 603-609.

Rochwerger L and Cuasnicu PS (1992) Redistribution of a rat sperm epididymal glycoprotein after in vitro and in vivo capacitation. Mol Reprod Dev 31, 34-41.

Romero MF and Boron WF (1999) Electrogenic Na+/HCO3— cotransporters: cloning and physiology. Annu Rev Physiol 61, 699-723.

Rotem R, Paz GF, Homonnai ZT, Kalina M and Naor Z (1990) Protein kinase C is present in human sperm: possible role in flagellar motility. Proc Natl Acad Sci USA 87, 7305-7308.

Roy S, Luetterforst R, Harding A et al. (1999) Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains. Nat Cell Biol 1, 98-105.

San Agustin JT, Leszyk JD, Nuwaysir LM and Witman GB (1998) The catalytic subunit of the cAMP-dependent protein kinase of ovine sperm flagella has a unique amino-terminal sequence. J Biol Chem 273, 24874-24883.

Sassone-Corsi P (1997) Transcriptional checkpoints determining the fate of male germ cells. Cell 88, 163-166.

Schulz JR, Wessel GM and Vacquier VD (1997) The exocytosis regulatory proteins syntaxin and VAMP are shed from sea urchin sperm during the acrosome reaction. Dev Biol 191, 80-87.

Schulz JR, Saski JD and Vacquier VD (1998) Increased association of synaptosome associated protein of 25 kDa with syntaxin and vessicle-associated membrane protein following acroso-mal exocytosis of sea urchin sperm. J Biol Chem 273,24355-24359.

Setchell BP, Maddocks S and Brooks DE (1994) Anatomy, vasculature, innervation, and fluids of the male reproductive tract. In: The Physiology of Reproduction, eds E Knobil and JD Neill, Vol. 1. New York: Raven Press, pp. 1063-1175.

Shadan S, James PS, Howes EA and Jones R (2004) Cholesterol efflux alters lipid raft stability and distribution during capacitation of boar spermatozoa. Biol Reprod 71, 253-265.

Shalgi R, Matityahu A, Gaunt SJ and Jones R (1990) Antigens on rat spermatozoa with a potential role in fertilization. Mol Reprod Dev 25,286-296.

Shi QX and Roldan ER (1995) Bicarbonate/CO2 is not required for zona pellucida- or progesterone-induced acrosomal exocytosis of mouse spermatozoa but is essential for capacitation. Biol Reprod 52, 540-546.

Simons K and Ikonen E (1997) Functional raits in cell membranes. Nature 387, 569-572.

Simons K and Ikonen E (2000) How cells handle cholesterol. Science 290,1721-1726.

Simons K and Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1,31-39.

Simons K and Vaz WL (2004) Model systems, lipid rafts, and cell membranes. Annu Rev Biophys Biomol Struct 33, 269-295.

Soskic V, Gorlach M, Poznanovic S, Boehmer FD and Godovac-Zimmermann J (1999) Functional proteomics analysis of signal transduction pathways of the platelet-derived growth factor beta receptor. Biochemistry 38,1757-1764.

Suzuki F and Yanagimachi R (1989) Changes in the distribution of intramembranous particles and filipin-reactive membrane sterols during in vitro capacitation of golden hamster spermatozoa. Gamete Res 23, 335-347.

Tesarik J and Flechon JE (1986) Distribution of sterols and anionic lipids in human sperm plasma membrane: effects of in vitro capacitation. J Ultrastruct Mol Struct Res 97,227-237.

Therien I, Soubeyrand S and Manjunath P (1997) Major proteins of bovine seminal plasma modulate sperm capacitation by high-density lipoprotein. Biol Reprod 57,1080-1088.

Tombes RM and Shapiro BM (1985) Metabolite channeling: a phosphorylcreatine shuttle to mediate high energy phosphate transport between sperm mitochondrion and tail. Cell 41, 325-334.

Travis AJ, Vargas LA, Merdiushev T, Moss SB, Hunnicutt GR and Kopf GS (2000) Expression and localization of caveolin-1 in mouse and guinea pig spermatozoa. Mol Biol Cell 11, 121a.

Trevino CL, Serrano CJ, Beltran C, Felix R and Darszon A (2001) Identification of mouse trp homologs and lipid rafts from spermatogenic cells and sperm. FEBS Lett 509, 119-125.

Uma Devi K, Jha K, Patil SB, Padma P and Shivaji S (2000) Inhibition of motility of hamster spermatozoa by protein tyrosine kinase inhibitors. Andrologia 32, 95-106.

Verkleij AJ, Zwaal RF, Roelofsen B, Comfurius P, Kastelijn D and van Deenen LL (1973) The asymmetric distribution of phospholipids in the human red cell membrane. A combined study using phospholipases and freeze-etch electron microscopy. Biochim Biophys Acta 323, 178-193.

Vijayaraghavan S, Olson GE, NagDas S, Winfrey VP and Carr DW (1997) Subcellular localization of the regulatory subunits of cyclic adenosine 3',5'-monophosphate-dependent protein kinase in bovine spermatozoa. Biol Reprod 57,1517-1523.

Vijayaraghavan S, Mohan J, Gray H, Khatra B and Carr DW (2000) A role for phosphorylation of glycogen synthase kinase-3alpha in bovine sperm motility regulation. Biol Reprod 62, 1647-1654.

Visconti PE and Kopf GS (1998) Regulation of protein phosphorylation during sperm capacitation. Biol Reprod 59, 1-6.

Visconti PE, Muschietti JP, Flawia MM and Tezon JG (1990) Bicarbonate dependence of cAMP accumulation induced by phorbol esters in hamster spermatozoa. Biochim Biophys Acta 1054, 231-236.

Visconti PE, Bailey JL, Moore GD, Pan D, Olds-Clarke P and Kopf GS (1995a) Capacitation of mouse spermatozoa. I. Correlation between the capacitation state and protein tyrosine phos-phorylation. Development 121, 1129-1137.

Visconti PE, Moore GD, Bailey JL et al. (1995b) Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway. Development 121,1139-1150.

Visconti PE, Olds-Clarke P, Moss SB, Kalab P, Travis AJ, de las Heras M and Kopf GS (1996) Properties and localization of a tyrosine phosphorylated form of hexokinase in mouse sperm. Mol Reprod Dev 43, 82-93.

Visconti PE, Johnson LR, Oyaski M, Fornes M, Moss SB, Gerton GL and Kopf GS (1997) Regulation, localization, and anchoring of protein kinase A subunits during mouse sperm capacitation. Dev Biol 192, 351-363.

Visconti PE, Galantino-Homer H, Moore GD, Bailey JL, Ning X, Fornes M and Kopf GS (1998) The molecular basis of sperm capacitation. J Androl 19, 242-248.

Visconti PE, Galantino-Homer H, Ning X et al. (1999a) Cholesterol efflux-mediated signal transduction in mammalian sperm. Beta-cyclodextrins initiate transmembrane signaling leading to an increase in protein tyrosine phosphorylation and capacitation. J Biol Chem 274, 3235-3242.

Visconti PE, Ning X, Fornes MW, Alvarez JG, Stein P, Connors SA and Kopf GS (1999b) Cholesterol efflux-mediated signal transduction in mammalian sperm: cholesterol release signals an increase in protein tyrosine phosphorylation during mouse sperm capacitation. Dev Biol 214, 429-443.

Visconti PE, Stewart-Savage J, Blasco A, Battaglia L, Miranda P, Kopf GS and Tezon JG (1999c) Roles of bicarbonate, cAMP, and protein tyrosine phosphorylation on capacitation and the spontaneous acrosome reaction of hamster sperm. Biol Reprod 61, 76-84.

Visconti PE, Westbrook VA, Chertihin O, Demarco I, Sleight S and Diekman AB (2002) Novel signaling pathways involved in sperm acquisition of fertilizing capacity. J Reprod Immunol 53, 133-150.

Wang D, King SM, Quill TA, Doolittle LK and Garbers DL (2003) A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility. Nat Cell Biol 5,1117-1122.

Ward CR and Kopf GS (1993) Molecular events mediating sperm activation. Dev Biol 158, 9-34.

Ward CR, Storey BT and Kopf GS (1992) Activation of a Gi protein in mouse sperm membranes by solubilized proteins of the zona pellucida, the egg's extracellular matrix. J Biol Chem 267, 14061-14067.

Wasco WM and Orr GA (1984) Function of calmodulin in mammalian sperm: presence of a calmodulin-dependent cyclic nuclearide phosphodiesterase associated with demembranated rat caudal epididymal sperm. Biochem Biophys Res Comm 118, 636-642.

Wiesner B, Weiner J, Middendorf R, Hagen V, Kaupp UB and Weyand I (1998) Cyclic nucleotide-gated channels on the flagellum control Ca2 + entry into sperm. J Cell Biol 142,473-484.

Wolf DE and Cardullo RA (1991) Physiological properties of the mammalian sperm plasma membrane. In: Comparative Spermatology 20 Years After, ed. B Baccetti. New York: Raven Press, pp. 599-604.

Wolf DE, Hagopian SS and Ishijima S (1986) Changes in sperm plasma membrane lipid dif-fusibility after hyperactivation during in vitro capacitation in the mouse. J Cell Biol 102, 1372-1377.

Wu C, Stojanov T, Chami O, Ishii S, Shimuzu T, Li A and O'Neill C (2001) Evidence for the autocrine induction of capacitation of mammalian spermatozoa. J Biol Chem 276, 26962-26968.

Yanagimachi R (1970) The movement of golden hamster spermatozoa before and after capacitation. J Reprod Fertil 23,193-196.

Yanagimachi R (1972) Penetration of guinea-pig spermatozoa into hamster eggs in vitro. J Reprod Fertil 28, 477-480.

Yanagimachi R (1994) Mammalian fertilization. In: The Physiology of Reproduction, eds. E Knobil and JD Neill, Vol. 1. New York: Raven Press, Ltd, pp. 189-317.

Yunes R, Michaut M, Tomes C and Mayorga LS (2000) Rab3A triggers the acrosome reaction in permeabilized human spermatozoa. Biol Reprod 62, 1084-1089.

Zachowski A (1993) Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement. Biochem J 294(Pt 1), 1-14.

Zajchowski LD and Robbins SM (2002) Lipid rafts and little caves. Compartmentalized signalling in membrane microdomains. Eur J Biochem 269, 737-752.

Zeng Y, Clark EN and Florman HM (1995) Sperm membrane potential: hyperpolarization during capacitation regulates zona pellucida-dependent acrosomal secretion. Dev Biol 171, 554-563.

Zeng Y, Oberdorf JA and Florman HM (1996) pH regulation in mouse sperm: identification of Na(+)-, Cl(—)-, and HCO3(—)-dependent and arylaminobenzoate-dependent regulatory mechanisms and characterization of their roles in sperm capacitation. Dev Biol 173, 510-520.

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