Humans reconciles variant phenotypes in diverse organisms

As reported in Moore et al., we identified 20 genes that encode proteins that potentially interacted with human DAZ/DAZL proteins via a yeast two-hybrid screen (Fig. 12.1) (Moore et al., 2003). Seven proteins, encoded by six genes (DZIP 1 and 2 are isoforms), interacted by strict criteria. Several observations suggested that we identified legitimate partners. First, five interacting proteins, like DAZ/DAZL, are

Gene

Expression

Motif(s)

PUM2

Male/female germ cells and ES cells

PUF repeat

hQK3

Upregulated in ovary and testis

None

BOL

Male germ cells

RRM, DAZ repeat

DZIP1

Testis and specific tissues

Zinc finger

DZIP2

Male germ cells

Zinc finger

DZIP3

Unknown

None

DAZL

Male/female germ cells

RRM, DAZ repeat

Figure 12.1 Genes that encode proteins that interact with the members of the DAZ protein family (see text for further discussion)

Figure 12.1 Genes that encode proteins that interact with the members of the DAZ protein family (see text for further discussion)

zoj:

BOULE DAZL

DAZL

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