Functional Relevance of GABAAReceptor Subtypes

Oscillatory activities are hallmarks of neuronal network functions. They contribute to information processing in a multitude of brain activities including cognitive functions. A key requirement for the generation of network oscillations is regular and synchronized neuronal activity. The temporal structure and spatial coherence of network oscillations is largely controlled by GABAergic interneurons. To provide the appropriate response characteristics the synaptic specialization of these...

Multiplicity of GABAa Receptors

As other members of the superfamily of ligand-gated ion channels that also include the nicotinic acetylcholine (nACh) receptor, the 5-hydroxytryptamine type-3 receptors, and the glycine receptors, GABAa receptors are made up of five subunits that can belong to different subunit classes (a, P, y, 5, e, n, 0, p). Within each class the subunits exhibit a 60-70 homology In between the classes the homology is only 30-40 (1,3). So far, a total of six a-, three P-, three y-, one 5-, one e-, one n-,...

Info

CREB, cAMP response element binding ATR4, activating transcription factor 4 CHOP, CCAT enhancer-binding protein (C EBP) homologous protein. CREB, cAMP response element binding ATR4, activating transcription factor 4 CHOP, CCAT enhancer-binding protein (C EBP) homologous protein. absence of any apparent change in the responsiveness of the GABAb receptor system (64). These findings indicate subunit proteins may serve functions in the cell, independent of their role as components of the GABAb...

Sl 651 498 Tpa 023

Modulatory site other than benzodiazepine site Ethanol Anxiolytic sedative High sensitivity (> 3 mM) at a4(a6) 3Sc, 93 medium sensitivity (> 30 mM) at a4(a6) 28c, low sensitivity (> 100 mM) at a4(a6) 3y2 Neurosteroids Anxiolytic, sedative, High sensitivity at 8-containing subtypesc 94 (e.g., 3a-, 5a-THDOC) anesthetic and at a,-, a3-receptors in combination with . Hypnotic Preferential affinity for a, 82 Hypnotic Preferential affinity for a, 82 Hypnotic Preferential affinity for a, 83...