Ahner A, Brodsky JL (2004) Checkpoints in ER-associated degradation: excuse me, which way to the proteasome? Trends Cell Biol 14:474-478 Antoniou AN, Ford S, Alphey M, Osborne A, Elliott T, Powis SJ (2002) The oxidoreduc-tase ERp57 efficiently reduces partially folded in preference to fully folded MHC class I molecules. EMBO J 21:2655-63 Argent RH, Parrott AM, Day PJ, Roberts LM, Stockley PG, Lord JM, Radford SE (2000) Ribosome-mediated folding of partially unfolded ricin A-chain. J Biol Chem 275:92639269

Bays NW, Gardner RG, Seelig LP, Joazeiro CA, Hampton RY (2001) Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol 3:24-29

Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D (2000) Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2:326332

Biederer T, Volkwein C, Sommer T (1996) Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway EMBO J 15:2069-2076

Biederer T, Volkwein C, Sommer T (1997) Role of Cuelp in ubiquitination and degradation at the ER surface. Science 278:1806-1809

Blom D, Hirsch C, Stern P, Tortorella D, Ploegh HL (2004) A glycosylated type I membrane protein becomes cytosolic when peptide:N-glycanase is compromised. EMBO J 23:650-658

Bordallo J, Plemper RK, Finger A, Wolf DH (1998) Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell 9:209-222

Brandizzi F, Hanton S, daSilva LL, Boevink P, Evans D, Oparka K, Denecke J, Hawes C (2003) ER quality control can lead to retrograde transport from the ER lumen to the cytosol and the nucleoplasm in plants. Plant J 34:269-281

Brodsky JL, Werner ED, Dubas ME, Goeckeler JL, Kruse KB, McCracken AA (1999) The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct. J Biol Chem 274:3453-3460

Buschhorn BA, Kostova Z, Medicherla B, Wolf DH (2004) A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins. FEBS Lett 577:422426

Cabral CM, Choudhury P, Liu Y, Sifers RN (2000) Processing by endoplasmic reticu-lum mannosidases partitions a secretion-impaired glycoprotein into distinct disposal pathways. J Biol Chem 275:25015-25022

Cabral CM, Liu Y, Moremen KW, Sifers RN (2002) Organizational diversity among distinct glycoprotein endoplasmic reticulum-associated degradation programs. Mol Biol Cell 13:2639-2650

Ceriotti A, Pedrazzini E, Fabbrini MS, Zoppe M, Bollini R, Vitale A (1991) Expression of the wild-type and mutated vacuolar storage protein phaseolin in Xenopus oocytes reveals relationships between assembly and intracellular transport. Eur J Biochem 202:959-968

Chillaron J, Haas IG (2000) Dissociation from BiP and retrotranslocation of unassembled immunoglobulin light chains are tightly coupled to proteasome activity. Mol Biol Cell 11:217-226

Chung DH, Ohashi K, Watanabe M, Miyasaka N, Hirosawa S (2000) Mannose trimming targets mutant a2-plasmin inhibitor for degradation by the proteasome. J Biol Chem 275:4981-4987

Coleman CE, Clore AM, Ranch JP, Higgins R, Lopes MA, Larkins BA (1997) Expression of a mutant a-zein creates the floury2 phenotype in transgenic maize. Proc Natl Acad Sci USA 94:7094-7097

D'Amico L, Valsasina B, Daminati MG, Fabbrini MS, Nitti G, Bollini R, Ceriotti A, Vitale A (1992) Bean homologs of the mammalian glucose-regulated proteins: induction by tunicamycin and interaction with newly synthesized seed storage proteins in the endoplasmic reticulum. Plant J 2:443-455

Day PJ, Pinheiro TJ, Roberts LM, Lord JM (2002) Binding of ricin A-chain to negatively charged phospholipid vesicles leads to protein structural changes and destabilizes the lipid bilayer. Biochemistry 41:2836-2843

Deeks ED, Cook JP, Day PJ, Smith DC, Roberts LM, Lord JM (2002) The low lysine content of ricin A chain reduces the risk of proteolytic degradation after translocation from the endoplasmic reticulum to the cytosol. Biochemistry 41:3405-3413 Denecke J, Goldman MH, Demolder J, Seurinck J, Botterman J (1991) The tobacco luminal binding protein is encoded by a multigene family. Plant Cell 3:1025-1235 Denecke J, Carlsson LE, Vidal S, Hoglund AS, Ek B, van Zeijl MJ, Sinjorgo KM, Palva ET (1995) The tobacco homolog of mammalian calreticulin is present in protein complexes in vivo. Plant Cell 7:391-406 de Virgilio M, Weninger H, Ivessa NE (1998) Ubiquitination is required for the retro-translocation of a short-lived luminal endoplasmic reticulum glycoprotein to the cytosol for degradation by the proteasome. J Biol Chem 273:9734-9743 de Virgilio M, Kitzmüller C, Schwaiger E, Klein M, Kreibich G, Ivessa NE (1999) Degradation of a short-lived glycoprotein from the lumen of the endoplasmic reticulum: the role of N-linked glycans and the unfolded protein response. Mol Biol Cell 10:4059-4073 Devoto A, Piffanelli P, Nilsson I, Wallin E, Panstruga R, von Heijne G, Schulze-Lefert P (1999) Topology, subcellular localization, and sequence diversity of the Mlo family in plants. J Biol Chem 274:34993-35004 Di Cola A, Frigerio L, Lord JM, Ceriotti A, Roberts LM (2001) Ricin A chain without its partner B chain is degraded after retrotranslocation from the endoplasmic reticulum to the cytosol in plant cells. Proc Natl Acad Sci USA 98:14726-14731 Di Cola A, Frigerio L, Lord JM, Roberts LM, Ceriotti A (2005) Endoplasmic reticulum-associated degradation of ricin A chain has unique and plant-specific features. Plant Physiol 137:287-296

Ellgaard L, Helenius A (2003) Quality control in the endoplasmic reticulum. Nat Rev Mol Cell Biol 4:1811-91

Ermonval M, Kitzmuller C, Mir AM, Cacan R, Ivessa NE (2001) N-glycan structure of a short-lived variant of ribophorin I expressed in the MadIA214 glycosylation-defective cell line reveals the role of a mannosidase that is not ER mannosidase I in the process of glycoprotein degradation. Glycobiology 11:565-576 Fagioli C, Sitia R (2001) Glycoprotein quality control in the endoplasmic reticulum. Mannose trimming by endoplasmic reticulum mannosidase I times the proteaso-mal degradation of unassembled immunoglobulin subunits. J Biol Chem 276:1288512892

Fagioli C, Mezghrani A, Sitia R (2001) Reduction of interchain disulfide bonds precedes the dislocation of Ig-^ chains from the endoplasmic reticulum to the cytosol for proteasomal degradation. J Biol Chem 276:40962-40967 Fang S, Ferrone M, Yang C, Jensen JP, Tiwari S, Weissman AM (2001) The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc Natl Acad Sci USA 98:14422-14427 Fayadat L, Siffroi-Fernandez S, Lanet J, Franc JL (2000) Degradation of human thyroper-oxidase in the endoplasmic reticulum involves two different pathways depending on the folding state of the protein. J Biol Chem 275:15948-15954 Fiebiger E, Story C, Ploegh HL, Tortorella D (2002) Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein. EMBO J 21:1041-1053 Foresti O, Frigerio L, Holkeri H, de Virgilio M, Vavassori S, Vitale A (2003) A phase-olin domain involved directly in trimer assembly is a determinant for binding by the chaperone BiP. Plant Cell 15:2464-2475 Frenkel Z, Gregory W, Kornfeld S, Lederkremer GZ (2003) Endoplasmic reticulum-associated degradation of mammalian glycoproteins involves sugar chain trimming to Man6_5GlcNAc2. J Biol Chem 278:34119-34124

Frigerio L, Vitale A, Lord JM, Ceriotti A, Roberts LM (1998) Free ricin A chain, proricin, and native toxin have different cellular fates when expressed in tobacco protoplasts. J Biol Chem 273:14194-14199 Frigerio L, Jolliffe NA, Di Cola A, Felipe DH, Paris N, Neuhaus JM, Lord JM, Ceriotti A, Roberts LM (2001) The internal propeptide of the ricin precursor carries a sequence-specific determinant for vacuolar sorting. Plant Physiol 126:167-175 Gillece P, Luz JM, Lennarz WJ, de La Cruz FJ, Romisch K (1999) Export of a cysteine-free misfolded secretory protein from the endoplasmic reticulum for degradation requires interaction with protein disulfide isomerase. J Cell Biol 47:1443-1456 Gnann A, Riordan JR, Wolf DH (2004) Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast. Mol Biol Cell 15:4125-4135 Hampton RY (2002) ER-associated degradation in protein quality control and cellular regulation. Curr Opin Cell Biol 14:476-482 Harding HP, Zhang Y, Ron D (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397:271-274 Hartley MR, Lord JM (2004) Cytotoxic ribosome-inactivating lectins from plants. Biochim

Biophys Acta 1701:1-14 Herscovics A (2001) Structure and function of Class I a1,2-mannosidases involved in gly-coprotein synthesis and endoplasmic reticulum quality control. Biochimie 83:757-762 Herscovics A, Romero PA, Tremblay LO (2002) The specificity of the yeast and human class I ER a1,2-mannosidases involved in ER quality control is not as strict as previously reported. Glycobiology 12:14G-15G Hill K, Cooper AA (2000) Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system. EMBO J 19:550-561 Hirsch C, Blom D, Ploegh HL (2003) A role for N-glycanase in the cytosolic turnover of glycoproteins. EMBO J 22:1036-1046 Hirsch C, Misaghi S, Blom D, Pacold ME, Ploegh HL (2004) Yeast N-glycanase distinguishes between native and non-native glycoproteins. EMBO Rep 5:201-206 Hong E, Davidson AR, Kaiser CA (1996) A pathway for targeting soluble misfolded proteins to the yeast vacuole. J Cell Biol 135:623-633 Hosokawa N, Wada I, Hasegawa K, Yorihuzi T, Tremblay LO, Herscovics A, Nagata K (2001) A novel ER a-mannosidase-like protein accelerates ER-associated degradation. EMBO Rep 2:415-422

Hosokawa N, Tremblay LO, You Z, Herscovics A, Wada I, Nagata K (2003) Enhancement of endoplasmic reticulum (ER) degradation of misfolded Null Hong Kong a-antitrypsin by human ER mannosidase I. J Biol Chem 278:26287-26294 Iwata Y, Koizumi N (2005) An Arabidopsis transcription factor, AtbZIP60, regulates the endoplasmic reticulum stress response in a manner unique to plants. Proc Natl Acad Sci USA 102:5280-5285 Jakob CA, Burda P, Roth J, Aebi M (1998) Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure. J Cell Biol 142:1223-1233 Jakob CA, Bodmer D, Spirig U, Battig P, Marcil A, Dignard D, Bergeron JJ, Thomas DY, Aebi M (2001) Htm1p, a mannosidase-like protein, is involved in glycoprotein degradation in yeast. EMBO Rep 2:423-430 Jarosch E, Taxis C, Volkwein C, Bordallo J, Finley D, Wolf DH, Sommer T (2002) Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat Cell Biol 4:134-139

Jolliffe NA, Ceriotti A, Frigerio L, Roberts LM (2003) The position of the proricin vacuolar targeting signal is functionally important. Plant Mol Biol 51:631-641 Kabani M, Kelley SS, Morrow MW, Montgomery DL, Sivendran R, Rose MD, Gierasch LM, Brodsky JL (2003) Dependence of endoplasmic reticulum-associated degradation on the peptide binding domain and concentration of BiP. Mol Biol Cell 14:34373448

Kikkert M, Hassink G, Barel M, Hirsch C, van der Wal FJ, Wierz E (2001) Ubiquitina-tion is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol. Biochem J 358:369-377 Kim CS, Hunter BG, Kraft J, Boston RS, Yans S, Jung R, Larkins BA (2004) A defective signal peptide in a 19-kD a-zein protein causes the unfolded protein response and an opaque endosperm phenotype in the maize De*-B30 mutant. Plant Physiol 134:380387

Kitzmüller C, Caprini A, Moore SE, Frenoy JP, Schwaiger E, Kellermann O, Ivessa NE, Ermonval M (2003) Processing of N-linked glycans during endoplasmic-reticulum-associated degradation of a short-lived variant of ribophorin I. Biochem J 376:687-696 Knittler MR, Dirks S, Haas IG (1995) Molecular chaperones involved in protein degradation in the endoplasmic reticulum: quantitative interaction of the heat shock cognate protein BiP with partially folded immunoglobulin light chains that are degraded in the endoplasmic reticulum. Proc Natl Acad Sci USA 92:1764-1768 Knop M, Finger A, Braun T, Hellmuth K, Wolf DH (1996a) Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast. EMBO J 15:753-763 Knop M,Hauser N, Wolf DH (1996b) N-Glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast. Yeast 12:1229-1238 Koizumi N (1996) Isolation and responses to stress of a gene that encodes a luminal binding protein in Arabidopsis thaliana. Plant Cell Physiol 37:862-865 Koizumi N, Martinez IM, Kimata Y, Kohno K, Sano H, Chrispeels MJ (2001) Molecular characterization of two Arabidopsis Ire1 homologs, endoplasmic reticulum-located transmembrane protein kinases. Plant Physiol 127:949-962 Leborgne-Castel N, Jelitto-Van Dooren EP, Crofts AJ, Denecke J (1999) Overexpression of

BiP in tobacco alleviates endoplasmic reticulum stress. Plant Cell 11:459-70 Liu Y, Choudhury P, Cabral CM, Sifers RN (1997) Intracellular disposal of incompletely folded human a1-antitrypsin involves release from calnexin and post-translational trimming of asparagine-linked oligosaccharides. J Biol Chem 272:7946-7951 Liu Y, Choudhury P, Cabral CM, Sifers RN (1999) Oligosaccharide modification in the early secretory pathway directs the selection of a misfolded glycoprotein for degradation by the proteasome. J Biol Chem 274:5861-5867 Lord JM, Ceriotti A, Roberts LM (2002) ER dislocation: Cdc48p/p97 gets into the AAAct. Curr Biol 12:R182-184

Lord JM, Deeks E, Marsden CJ, Moore K, Pateman C, Smith DC, Spooner RA, Watson P, Roberts LM (2003) Retrograde transport of toxins across the endoplasmic reticulum membrane. Biochem Soc Trans 31:1260-1262 Lilley BN, Ploegh HL (2004) A membrane protein required for dislocation of misfolded proteins from the ER. Nature 429:834-840 Lupattelli F, Pedrazzini E, Bollini R, Vitale A, Ceriotti A (1997) The rate of phaseolin assembly is controlled by the glucosylation state of its N-linked oligosaccharide chains. Plant Cell 9:597-609

Mancini R, Fagioli C, Fra AM, Maggioni C, Sitia R (2000) Degradation of unassembled soluble Ig subunits by cytosolic proteasomes: evidence that retrotranslocation and degradation are coupled events. FASEB J 14:769-778

Mancini R, Aebi M, Helenius A (2003) Multiple endoplasmic reticulum-associated pathways degrade mutant yeast carboxypeptidase Y in mammalian cells. J Biol Chem 278:46895-46905

Marocco A, Santucci A, Cerioli S, Motto M, Di Fonzo N, Thompson R, Salamini F (1991) Three high-lysine mutations control the level of ATP-binding HSP70-like proteins in the maize endosperm. Plant Cell 3:507-515 Martinez IM, Chrispeels MJ (2003) Genomic analysis of the unfolded protein response in Arabidopsis shows its connection to important cellular processes. Plant Cell 15:561-576 Matsuoka K, Seta K, Yamakawa Y, Okuyama T, Shinoda T, Isobe T (1994) Covalent structure of bovine brain calreticulin. Biochem J 298:435-442 Medicherla B, Kostova Z, Schaefer A, Wolf DH (2004) A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation. EMBO Rep 5:692697

Molinari M, Galli C, Piccaluga V, Pieren M, Paganetti P (2002) Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER. J Cell Biol 158:247-257 Molinari M, Calanca V, Galli C, Lucca P, Paganetti P (2003) Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle. Science 299:1397-1400 Müller J, Piffanelli P, Devoto A, Miklis M, Elliott C, Ortmann B, Schulze-Lefert P, Panstruga R (2005) Conserved ERAD-like quality control of a plant polytopic membrane protein. Plant Cell 17:149-163 Nakatsukasa K, Nishikawa S, Hosokawa N, Nagata K, Endo T (2001) Mnl1p, an a-mannosidase-like protein in yeast Saccharomyces cerevisiae, is required for endoplasmic reticulum-associated degradation of glycoproteins. J Biol Chem 276:8635-8638 Navazio L, Miuzzo M, Royle L, Baldan B, Varotto S, Merry AH, Harvey DJ, Dwek RA, Rudd PM, Mariani P (2002) Monitoring endoplasmic reticulum-to-Golgi traffic of a plant calreticulin by protein glycosylation analysis. Biochemistry 41:14141-14149 Nebenführ A, Ritzenthaler C, Robinson DG (2002) Brefeldin A: deciphering an enigmatic inhibitor of secretion. Plant Physiol 130:1102-1108 Nishikawa SI, Fewell SW, Kato Y, Brodsky JL, Endo T (2001) Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation. J Cell Biol 153:1061-1070 Noh SJ, Kwon CS, Oh DH, Moon JS, Chung WI (2003) Expression of an evolutionarily distinct novel BiP gene during the unfolded protein response in Arabidopsis thaliana. Gene 311:81-91

Oda Y, Hosokawa N, Wada I, Nagata K (2003) EDEM as an acceptor of terminally mis-

folded glycoproteins released from calnexin. Science 299:1394-1397 Okada T, Yoshida H, Akazawa R, Negishi M, Mori K (2002) Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochem J 366:585-594 Okamura K, Kimata Y, Higashio H, Tsuru A, Kohno K (2000) Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast. Biochem Biophys Res Commun 279:445-450 Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (2005) A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation. J Biol Chem 280:2424-2428

Park H, Suzuki T, Lennarz WJ (2001) Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation. Proc Natl Acad Sci USA 98:11163-11168

Pedrazzini E, Giovinazzo G, Bollini R, Ceriotti A, Vitale A (1994) Binding of BiP to an assembly-defective protein in plant cells. Plant J 5:103-110 Pedrazzini E, Giovinazzo G, Bielli A, de Virgilio M, Frigerio L, Pesca M, Faoro F, Bollini R, Ceriotti A, Vitale A (1997) Protein quality control along the route to the plant vacuole. Plant Cell 9:1869-1880 Pilon M, Schekman R, Romisch K (1997) Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation. EMBO J 16:4540-4548

Plemper RK, Bohmler S, Bordallo J, Sommer T, Wolf DH (1997) Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation. Nature 388:891-895

Rabinovich E, Kerem A, Frohlich KU, Diamant N, Bar-Nun S (2002) AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation. Mol Cell Biol 22:626-634 Richly H, Rape M, Braun S, Rumpf S, Hoege C, Jentsch S (2005) A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting. Cell 120:73-84 Sato M, Sato K, Nakano A (2004) Endoplasmic reticulum quality control of unassembled iron transporter depends on Rer1p-mediated retrieval from the Golgi. Mol Biol Cell 15:1417-1424

Schmitz A, Schneider A, Kummer MP, Herzog V (2004) Endoplasmic reticulum-localized amyloid ^-peptide is degraded in the cytosol by two distinct degradation pathways. Traffic 5:89-101

Schubert U, Anton LC, Gibbs J, Norbury CC, Yewdell JW, Bennink JR (2000) Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature 404:770-774

Shearer AG, Hampton RY (2005) Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. EMBO J 24:149-159 Simpson JC, Roberts LM, Romisch K, Davey J, Wolf DH, Lord JM (1999) Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast. FEBS Lett 459:80-84 Skowronek MH, Hendershot LM, Haas IG (1998) The variable domain of nonassembled Ig light chains determines both their half-life and binding to the chaperone BiP. Proc Natl Acad Sci USA 95:1574-1578 Sparvoli F, Faoro F, Daminati MG, Ceriotti A, Bollini R (2000) Misfolding and aggregation of vacuolar glycoproteins in plant cells. Plant J 24:825-836 Spooner RA, Watson PD, Marsden CJ, Smith DC, Moore KA, Cook JP, Lord JM, Roberts LM (2004) Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum. Biochem J 383:285-293 Su K, Stoller T, Rocco J, Zemsky J, Green R (1993) Pre-Golgi degradation of yeast prepro-a-factor expressed in a mammalian cell. Influence of cell type-specific oligosaccharide processing on intracellular fate. J Biol Chem 268:14301-14309 Suzuki T, Lennarz WJ (2003) Hypothesis: a glycoprotein-degradation complex formed by protein-protein interaction involves cytoplasmic peptide:N-glycanase. Biochem Bio-phys Res Commun 302:1-5 Suzuki T, Park H, Hollingsworth NM, Sternglanz R, Lennarz WJ (2000) PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase. J Cell Biol 149:1039-1052 Suzuki T, Park H, Till EA, Lennarz WJ (2001) The PUB domain: a putative protein-protein interaction domain implicated in the ubiquitin-proteasome pathway. Biochem Biophys Res Commun 287:1083-1087

Swanson R, Locher M, Hochstrasser M (2001) A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Mata2 repressor degradation. Genes Dev 15:2660-2674 Tamura K, Yamada K, Shimada T, Hara-Nishimura I (2004) Endoplasmic reticulum-resident proteins are constitutively transported to vacuoles for degradation. Plant J 39:393-402

Taxis C, Hitt R, Park SH, Deak PM, Kostova Z, Wolf DH (2003) Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD. J Biol Chem 278:35903-35913 Tirosh B, Furman MH, Tortorella D, Ploegh HL (2002) Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation. J Biol Chem 278:6664-6672 Tortorella D, Story CM, Huppa JB, Wiertz EJ, Jones TR, Bacik I, Bennink JR, Yewdell JW, Ploegh HL (1998) Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential. J Cell Biol 142:365-376 Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS, Walter P (2000) Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101:249-258 Tsai B, Rodighiero C, Lencer WI, Rapoport TA (2001) Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin. Cell 104:937-948 Vashist S, Kim W, Belden WJ, Spear ED, Barlowe C, Ng DT (2001) Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding. J Cell Biol 155:355-368 Vierstra RD (2003) The ubiquitin/26S proteasome pathway, the complex last chapter in the life of many plant proteins. Trends Plant Sci 8:135-142 Wang Q, Chang A (2003) Substrate recognition in ER-associated degradation mediated by

Eps1, a member of the protein disulfide isomerase family. EMBO J 22:3792-3802 Wesche J, Rapak A, Olsnes S (1999) Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol. J Biol Chem 274:3444334449

Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL (1996) Sec61-mediated transfer of a membrane protein from the endoplasmic reticu-lum to the proteasome for destruction. Nature 384:432-438 Wilson CM, Farmery MR, Bulleid NJ (2000) Pivotal role of calnexin and mannose trimming in regulating the endoplasmic reticulum-associated degradation of major histocompatibility complex class I heavy chain. J Biol Chem 275:21224-21232 Yamamoto K, Fujii R, Toyofuku Y, Saito T, Koseki H, Hsu VW, Aoe T (2001) The KDEL receptor mediates a retrieval mechanism that contributes to quality control at the endoplasmic reticulum. EMBO J 20:3082-3091 Ye Y, Meyer HH, Rapoport TA (2001) The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature 414:652-656 Ye Y, Meyer HH, Rapoport TA (2003) Function of the p97-Ufd1-Npl4 complex in retro-translocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol 162:71-84 Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA (2004) A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature 429:841-847 Yoshida Y, Chiba T, Tokunaga F, Kawasaki H, Iwai K, Suzuki T, Ito Y, Matsuoka K, Yoshida M, Tanaka K, Tai T (2002) E3 ubiquitin ligase that recognizes sugar chains. Nature 418:438-442

Yoshida H, Matsui T, Hosokawa N, Kaufman RJ, Nagata K, Mori K (2003a) A time-dependent phase shift in the mammalian unfolded protein response. Dev Cell 4:265-271

Yoshida Y, Tokunaga F, Chiba T, Iwai K, Tanaka K, Tai T (2003b) Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. J Biol Chem 278:4387743884

Zhang Y, Nijbroek G, Sullivan ML, McCracken AA, Watkins SC, Michaelis S, Brodsky JL (2001) Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast. Mol Biol Cell 12:1303-1314

Zhou M, Schekman R (1999) The engagement of Sec61p in the ER dislocation process. Mol Cell 4:925-934

Plant Cell Monogr (4)

D.G. Robinson: The Plant Endoplasmic Reticulum

DOI 10.1007/7089_054/Published online: 15 February 2006

© Springer-Verlag Berlin Heidelberg 2006

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