Contents

5.1 Introduction 79

5.2 High-Throughput Screening Today: The High-Quality Automated Assay 81

5.2.1 Automation 81

5.2.2 The Sample Library 84

5.2.3 Biochemical Assays 86

5.2.4 Cellular Assays 90

5.2.5 The Drive to Miniaturize 91

5.2.6 Data Analysis 92

5.3 The Expanding Use of Higher Throughput Assays 92

5.4 The Road Ahead 95

5.5 Conclusions 96

References 97

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