If TGL 200 mgdL nonHDLC total C minus HDL is a secondary target of therapy with a goal of 30 mgdL higher than the LDL goal

Table 4

The range of the lipid effects of commonly used drugs

Table 4

The range of the lipid effects of commonly used drugs

Drug

LDL cholesterol (%)

HDL cholesterol (%)

Triglycerides (%)

Statins

-18 to —55

+5 to +15

-7 to -30

Fibrates

—5 to —20*

+ 10 to +20

-20 to -50

Niacin

—5 to —25

+ 15 to +35

-20 to -50

Bile acid sequestrants

— 15 to —30

+3 to +5

No change or increase

Ezetimibe

— 15 to —20

+ 1 to +2

-5 to -10

*, may increase in patients with high triglycerides.

Adapted from Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in adults (Adult Treatment Panel III). JAMA 2001;285(19):2486-97, with permission; and Gagne C, Bays HE, Weiss SR, Mata P, Quinto K, Melino M, et al. Efficacy and safety of ezetimibe added to ongoing statin therapy for treatment of patients with primary hypercholesterolemia. Am J Cardiol 2002;90(10):1084-91; with permission.

*, may increase in patients with high triglycerides.

Adapted from Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in adults (Adult Treatment Panel III). JAMA 2001;285(19):2486-97, with permission; and Gagne C, Bays HE, Weiss SR, Mata P, Quinto K, Melino M, et al. Efficacy and safety of ezetimibe added to ongoing statin therapy for treatment of patients with primary hypercholesterolemia. Am J Cardiol 2002;90(10):1084-91; with permission.

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