Pharmacological trials

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Dutch Acarbose Trial (DAISI)

A three-year primary prevention study is underway in Hoorn, the Netherlands, also using acarbose among 150 subjects with IGT. After screening of potentially eligible subjects, those who have a mean of two fasting plasma glucose levels <7.8 mmol/l (140 mg/dl) and the mean of two 2 h post-load glucoses >8.6 - <11.1 mmol/l (>155.0 - <200 mg/dl) have been randomized to either 50 mg of acarbose three times a day or placebo. Subjects will have three-monthly fasting glucose levels, and an OGTT at 1.5 and three years for the primary endpoint of type 2 diabetes. A useful addition to this small trial is the performance of a hyperglycemic clamp at randomization and at three years to assess insulin resistance. Completion is expected in 2002.

Table 6.8. Primary prevention trials for type 2 diabetes mellitus underway as of 2002.

Study, author,

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