Dutch Acarbose Trial (DAISI)
A three-year primary prevention study is underway in Hoorn, the Netherlands, also using acarbose among 150 subjects with IGT. After screening of potentially eligible subjects, those who have a mean of two fasting plasma glucose levels <7.8 mmol/l (140 mg/dl) and the mean of two 2 h post-load glucoses >8.6 - <11.1 mmol/l (>155.0 - <200 mg/dl) have been randomized to either 50 mg of acarbose three times a day or placebo. Subjects will have three-monthly fasting glucose levels, and an OGTT at 1.5 and three years for the primary endpoint of type 2 diabetes. A useful addition to this small trial is the performance of a hyperglycemic clamp at randomization and at three years to assess insulin resistance. Completion is expected in 2002.
Table 6.8. Primary prevention trials for type 2 diabetes mellitus underway as of 2002.
Was this article helpful?
All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.