Pjs And Pc

Rosacea Free Forever

Rosacea Free Forever Cure

Get Instant Access

Table 25.2 focuses on PJS and its association with PC. PJS is a rarely occurring disorder; yet the review of Yee et al.34 indicates that there is an extensive knowledge base on PJS relevant to its multifaceted clinical and pathological features of PC and, when indicated, its association with other tumors. Review of Table 25.2 shows the extensive knowledge base accrued on PC's association with PJS.

Table 25.1 Genetic Syndromes with Inherited Predisposition to Pancreatic Cancer

Relative

Relative

Table 25.1 Genetic Syndromes with Inherited Predisposition to Pancreatic Cancer

Familial Syndromea

Gene (Locus)

Risk

Frequencyb

References

Peutz-Jeghers

STK11/LKB1

132

4%

97-102

syndrome

(19p13.3)

Familial

Cationic

50-60

Unknown

30,31,103

pancreatitis

trypsinogen (7q35)

Familial pancreatic

Unknown

18-57

Unknown

104,105

cancer syndrome

(4q32-34)

FAMMM syndrome

pi6INK4a/MTSi (9p21)

13-22

98%

46,106-108

Hereditary

BRCA2 (13q12)

10

7%

56,109,110

breast-ovarian

cancer syndrome

Familial

APC (5q21)

5

40%

20,111-115

adenomatous

polyposis

HNPCCc

hMSH2 (2p22-21) hMLH1 (3p21.3)

Unknown

4-11%

116-118

Ataxia

ATM (11q22-23)

Unknown

Unknown

41,119

telangiectasia

a All of the above syndromes are inherited in an autosomal dominant fashion, except ataxia telangiectasia, which is an autosomal recessive disorder.

b Frequency refers to the frequency of genetic mutation found in sporadically occurring pancreatic carcinomas.

c HNPCC — hereditary nonpolyposis colorectal cancer, also known as cancer family syndrome or Lynch Syndrome II. HNPCC is typically caused by germ line mutations in DNA mismatch repair genes including hMSH2, hMLH1, hPMS2, and hMSH6. hMSH2 and hMLH1 mutations account for one-half to two-thirds of HNPCC. The frequency refers to a defect in any one of the five DNA mismatch repair genes causing HNPCC.

Source: Reproduced by permission from Yee et al. 2003. Cancer Biol. Ther. 2(1):38-47.

Was this article helpful?

0 0
How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

Get My Free Ebook


Post a comment