M Sambasiva Rao and Janardan K Reddy Contents

18.1 Introduction 356

18.1.1 Liver and Pancreatic Diseases — Use of Stem Cell Transplantation 357

18.1.2 Lineage Switches of Cells — Definitions 357

18.1.3 Pancreatic Hepatocytes 358

18.2 Experimental Models of Pancreatic Hepatocytes 358

18.2.1 Hamster Model 358

18.2.2 Mouse Model 359

18.2.3 Rat Models 359

18.2.3.1 Ciprofibrate Model 359

18.2.3.2 Methionine-Deficient Diet Model 360

18.2.3.3 Dichloro-P-Phenylenediamine Model 360

18.2.3.4 Cadmium Chloride Model 360

18.2.3.5 Spontaneous Hepatocyte Development 360

18.2.3.6 Copper-Deficiency Model 360

18.3 Origin of Pancreatic Hepatocytes 368

18.3.1 Ductular and Oval Cells as the Progenitor Cells of

Pancreatic Hepatocytes 368

18.3.2 Differentiation Potential of Oval and Ductular Cells

— In Vitro and In Vivo Studies 369

18.4 Possible Mechanisms Involved in the Induction of Pancreatic Hepatocytes 370

18.5 Epilogue 371

Acknowledgments 371

References 371

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