Embedded within the exocrine pancreas, pancreatic islets distinguish themselves from the surrounding tissue in several aspects, including toxicology. As a gatekeeper tissue of the pancreas,1 it is equipped with a greater concentration of drug-metabolizing enzymes than the exocrine tissue (see Chapter 7). Moreover, several P450 enzymes are selectively expressed in islet cells. Consequently, some toxins primarily or exclusively affect the islet cells. Although the numbers of endocrine cell toxins have not been sufficiently sought out, a few toxins have been the subject of intense investigation. Streptozotocin (STZ) and alloxan are the most studied compounds.
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All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.