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Local insulin in the pancreas appears to be important for hormonal actions of secretin and CCK. It has been shown in rats that upon immunoneu-tralization of endogenous insulin, postprandial PES is impeded and the physiological doses of secretin and CCK are unable to stimulate PES.16 Similar effects of immunoneutralization of insulin have been observed in isolated and perfused rat and dog pancreata suggesting that insulin plays a local regulatory role. It is likely that endogenous insulin plays a permissive role for the actions of secretin and CCK (Section 6.17). For additional information, see Chapter 13 and Chapter 14.

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