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Data taken from [8,37,38,43,78,126-131].

Data taken from [8,37,38,43,78,126-131].

(1.5-4.5 liter/kg) typical of the class. Protein binding is generally 50% or less (48% for moxifloxacin and 20% for gatifloxacin), although it is higher (70%) for trovafloxacin. After oral administration, the fluoroquinolones produce levels well in excess of those required for clinical efficacy in genitourinary, gynecological, skeletal, and other important tissues and fluids [35]. They are particularly well concentrated in target tissues within the respiratory tract, matching optimal kinetics with improved potency against respiratory pathogens.

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