History and Overview

Peter Ball

Senior Lecturer (Honorary), School of Biomedical Sciences, University of St. Andrews, St. Andrews, Fife KY16 9AL, Scotland, United Kingdom

Introduction

Structure-Activity Relationships (SARs) Antibacterial Activity Mode of Action Spectrum of Activity Bacterial Resistance to Fluoroquinolones Clinical Pharmacology

Penetration into Respiratory Tissues Elimination Pathways Pharmacodynamics of Quinolones Clinical Uses

Urinary Tract Infections Sexually Transmitted Diseases Respiratory Infections Gastrointestinal Infections Skin and Soft Tissue Infections Bone Infections Neutropenic Cancer Patients Prophylaxis

Pharmacoeconomic Aspects of Fluoroquinolone Usage Use of Fluoroquinolones in Pediatrics Adverse Drug Reactions Interactions with Other Drugs Interactions Reducing Absorption Metabolic and Inhibitory Interactions Conclusion References

The Quinolones, Third Edition

Copyright © 2000 by Academic Press. All rights of reproduction in any form reserved.

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