Gastrointestinal Infections

The fluoroquinolones have proved a major advance in management of many forms of moderate to severe enteric infection [64]. Administered for 10 days, they are the drugs of choice for oral management of typhoid fever in both adults and children, reducing complication, relapse, and convalescent excretion rates to a greater extent than comparator antibiotics [65,66]. Ciprofloxacin has good efficacy in moderate to severe shigellosis [67], in which single-dose therapy is one of the regimens of choice [64] and is as effective as tetracyclines in cholera [68]. Fluoroquinolones are effective in both the treatment, even single-dose [69], and prophylaxis of traveler's diarrhea [70]. They are also agents of choice in the management of invasive salmonellosis in AIDS patients. However, empirical therapy of acute bacterial diarrhoea is not generally recommended, and the role of fluoroquinolones in noninvasive salmonellosis remains controversial. Early trials suggested efficacy, but failure to eradicate pathogens has proved to be a problem [64,71]. Fluoroquinolones are ineffective in campylobacteriosis.

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