Clinical Pharmacology

The basic pharmacokinetic parameters of fluoroquinolones are given in Table III. The newer generation, that is, sparfloxacin, trovafloxacin, grepafloxacin, cli-nafloxacin, moxifloxacin, and gatifloxacin, are similar in this regard to previous group members [34,37] (see Chapter 5). Levofloxacin has kinetics like those of ofloxacin.

All fluoroquinolones are well absorbed, reach peak serum concentrations within 1-2 hours (sparfloxacin 4-5 hr), and have high distribution volumes

TABLE III Pharmacokinetic Parameters for Representative Fluoroquinolones
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