Histological Search for Angiogenic Factors

The vascular proliferation seen in the skin of patients with venous disease has been known for many years, but has not been explained. In recent years many angiogenic factors that stimulate the growth of blood vessels have been recognized. Immunohistochemistry was used to evaluate the presence of a number of such factors in the skin of patients with venous disease.40 Skin biopsies were taken at the time of surgery for varicose veins from the legs of patients with and without skin changes as well as of breast skin in patients without clinical evidence of venous disease, for use as a control. There was an increase in platelet derived growth factor, subtype BB (PDGF-BB) in patients with venous disease. This was found in the capillary wall in vessels of the dermal papillae. There was also considerable upregula-tion of the production of vascular endothelial growth factor (VEGF) in the epidermis of patients with venous disease, most marked in those with skin changes. It seems likely that VEGF may account for at least some of the vascular prolif-

0 0

Post a comment