Introduction

Identification of the platelet-derived growth factor (PDGF) family began with the annotation of functional serum activity and thereafter differentiated among the unique primary structures of PDGF-A and PDGF-B that have been intimately associated with

From: Cancer Drug Discovery and Development: The Oncogenomics Handbook Edited by: W. J. LaRochelle and R. A. Shimkets © Humana Press Inc., Totowa, NJ

malignant transformation, neovascularization, and tumor-stromal interactions. In notable contrast, the widespread use of genomic technologies, including transcript libraries and databases, led to the ability to perform homology-based searches and the discovery of the unique primary sequences of other family members: PDGF-C and PDGF-D. Subsequent functional studies have shown that the new PDGFs are each pleiotropic growth factors for cells expressing PDGF receptors. As ligands for the a and/or P PDGF receptors, these new PDGFs have been associated with several disease states. Here, we will focus on the discovery, structure, and function of PDGF-D, a latent, protease-activated growth factor that has recently been implicated in the development of various types of cancer and kidney disease.

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