Epigenetics and cancer

Genetic alterations are the hallmark of neoplastic evolution, as suggested by the analysis of chromosomal structure and determining the chromosomal number (31). Based on the information available today, epigenetics is considered to play a minor role in cancer development compared to genetic events (32). However, recent data suggest alternate approaches that have focused the attention on the contribution of epigenetics to tumorigenesis. Cancer appears to be a process that is developed both by mutations in DNA and by epigenetic mechanisms. These processes can complement such that one can predispose to the other in inducing cancer development.

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