Info

Monkeys

Urinary tract

Glycopeptides (from serum glycoproteins)

E. coli K99

Calves

Gut

Galactose, mannose and N-acetylglucosamine

P. aeruginosa

Human

Ear

Sialyl containing oligosaccharide

H. pylori

Piglet

Gut

GalNAcb4Gal containing oligosaccharide

S. pneumoniae

Rabbit

Lung

N-Acetylglucosamine

S. pneumoniae

Mouse

Lung

Gal, galactose; GalNAc, N-acetylgalactosamine. "Adapted from Sharon, 1996.

serve as a critical reservoir from which reinfection of the host can take place.

The mechanisms employed by various bacteria to gain access into nonphagocytic cells are diverse and often complex (see range of molecules implicated in bacterial invasion of host cells in Table 7). For example, Yersinia enterolitica employs a single cell surface protein, invasin, whose cognate receptors on the host cell membrane are b integrins (Isberg, 1996). When inva-sin binds with high affinity to b integrins, the close association between the integrins and cytoskeletal elements of the cell membrane triggers the bacterial uptake. Particles that are

Table 7. Examples of bacteria capable of invading nonphagocytic cells.
0 0

Post a comment