Seven Secrets To Reverse Your Osteopenia

The Osteoporosis Reversing Breakthrough

eres just a few things youll learn about how to get back into health. and conquer Osteoporosis. Those not-so innocent yet everyday substances that are currently attacking your body, perpetuating and aggravating your Osteoporosis. What to do and what Not to do to overcome your Osteoporosis effectively and permanently. How to create the energy you need to be able to work full time and feel confident you will be able to take care of your loved ones. How the pharmaceutical and food industry are conspiring to poison you and make you sick (Hint: American medical system is now the leading cause of death in the US). Which food industries use advertising to encourage doctors to tell you that their food is good for you just like those cigarette ads in the 1950s! The single most effective fruits and vegetables in cleaning up excess acidic waste and how to cleanse your inner terrain completely from systemic acidosis. Why, what your Doctor has told you is wrong, and why many medications actually increase the side effects and complications of Osteoporosis (primarily by depleting vital vitamins, minerals and nutrients from your body). Which supplements every patient must take to stop the symptoms and boost your body's ability to reverse Osteoporosis. How to naturally reduce your cravings for toxic foods. Lifestyle and food choices to reverse your Osteoporosis fast, naturally, and for good. Why treating the symptoms of disease is like using an umbrella inside your house instead of fixing the roof. The most powerful creator of health (Hint: its not a food or vitamin!) The best way to simplify the task of making a health-conscious lifestyle adjustment. A miraculous scientific discovery that jump-starts your body to do its natural work, which is to heal itself and restore your Health.

The Osteoporosis Reversing Breakthrough Overview


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The Truth About Osteoporosis

Discover Easy Strategies To Maintain Optimal Bone Health And Reverse Osteoporosis. Here is a quick preview of the valuable information youll have at your fingertips: Statistics can lead to false conclusions. Bone Quality or Quantity? Density or Strength? Find what matters! What happens to unabsorbed calcium? How do prescribed medications fit in the equation? What is the 4-R Program and can it help reverse osteoporosis? What part does protein play in bone health? What contribution does lifestyle make? Am I unknowingly my own worst enemy? What about inflammation and stress? How do they impact my bones?Does an acidic system affect the progress of osteoporosis? Who would suspect this sneaky culprit (in your tap water) as contributing to loss of bone health? Discover 4 easy steps for relieving stress. What part do hormones play in osteoporosis? How to encourage new bone growth. Find 7 steps to a workable exercise program. Look at the whole body. 12 steps to changing habits effortlessly.

The Truth About Osteoporosis Overview

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Author: Shirley Alsop
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Bone mineral density and fractures

In the presence of adequate dietary calcium, 1,25-OHD increases bone formation and growth plate mineralisation by providing sufficient calcium to allow calcification to occur. In contrast, prolonged vitamin D deficiency results in a poorly mineralised skeleton. When calcium is limited the skeleton is sacrificed because appropriate concentrations of calcium are required for vital nerve and muscle activity. Seasonal increases in PTH may have an adverse effect on bone loss. It is known that accelerated bone loss occurs in hyperparathyroidism (Maxwell, 2001) and increased PTH activity is a determinant in vertebral osteoporosis. However, studies by Krall and Dawson-Hughes (1991) showed that serum concentrations of 25-OHD > 95nmol L prevent a seasonal increase in PTH. This suggests that when vitamin D status is poor, PTH stimulates 1,25-OHD production, which acts primarily on the bone to release calcium for essential activities. When vitamin D status is good, sufficient 1,25-OHD is...

Dietary components and health

The general increase, however, in the quantity and variety of food available has mostly been accompanied by the emergence of degenerative conditions such as CVD, various types of cancer, non-insulin dependent diabetes mellitus, obesity, osteoporosis and hypertension. Documenting and monitoring dietary patterns has therefore become a priority in the formulation of dietary recommendations and the planning of national food, nutrition and agricultural policies (Soci t Fran aise de Sant Publique. Health and Human Nutrition, 2000).

Definition of Disease

Abnormalities may be seen in this setting, which range from high-turnover bone disease due to secondary hyperparathyroidism, known as osteitis fibrosa in its severe form, to the opposite end of the spectrum of bone turnover, where it can be excessively low and give rise to a skeletal abnormality known as adynamic bone disease. Some patients may also have mineralization defects in the skeleton, which may be manifested as osteomalacia. In many patients, there is evidence of both high bone turnover together with mineralization defects of bone, and this is termed mixed renal osteodystrophy. Abnormalities of the skeleton are extremely common in patients with advanced kidney diseases, even in the absence of symptoms, and symptomatic bone disease in this patient population is relatively unusual nowadays. It is important to recognize that other forms of skeletal disease may also coexist in these patients, and therefore, this patient, who is a postmenopausal female, who had been treated with...

Differential Diagnosis

There are several considerations in this patient that could account for her symptoms. The initial consideration is that she had hyperparathyroid bone disease, as a result of secondary hyperparathyroidism. In this regard, measurements of intact PTH had ranged within 300-400 pg mL, which is clearly above the normal interval for these PTH assays, in which the upper limit of normal would be approximately 65 pg mL. While at first glance this may indicate severe hyperparathyroidism, it is important to note that in the setting of advanced chronic kidney disease, there is known to be skeletal resistance to the actions of PTH, and higher than normal concentrations of PTH appear to be required to maintain bone turnover. In recent times, clinical practice guidelines have been introduced for the control of the abnormalities of mineral metabolism in patients with chronic kidney disease, and it is recommended that intact PTH should ideally be maintained between 150 and 300 pg mL in order to...

Beneficial And Adverse Effects Of Phytoestrogens In Humans

The bulk of the available data on the effects of phytoestrogen on humans is mostly from postmenopausal women, and in particular on the effects on hot flushes. Data are beginning to emerge on the effect of phytoestrogens in bone, but very little is known about the effects of these compounds on the uterus and breast. This information is urgently required to allow evaluation of long-term safety of these compounds, particularly in view of long-term treatment of postmenopausal women for the prevention of osteoporosis. Very little is known about the therapeutic potential of phytoestrogen in men.

Selective Estrogen Receptor Modulators

These new drugs, sometimes called designer estrogens, appear to affect blood lipids in much the same way that estrogen does but possibly without the increased risk for breast cancer and endome-trial cancer associated with hormone replacement therapy. Raloxifene (Evista), one of these drugs, has been shown to decrease levels of LDL, but unlike estrogen does not reliably elevate HDL cholesterol, though it may increase one of the HDL subfractions. Also unlike estrogen, raloxifene doesn't elevate triglyceride levels. Raloxifene is approved for osteoporosis prevention, and recent preliminary studies suggest that it may be effective at reducing breast cancer risk. Like estrogen, however, it does increase the risk of blood clots in the legs. Overall, I don't use raloxifene as a pri- 33. mary treatment for lipid problems, but if a woman needs a drug to treat her osteoporosis, raloxifene's generally favorable effects on lipids make it a reasonable choice. If further trials show that this drug...

Neuromuscular Reanimation

The first clinical applications of this technology have aimed to prevent or reverse disuse atrophy of paretic muscles (Dupont et al., 2004). One clinical trial now under way involves stimulation of the middle deltoid and supraspinatus muscles of stroke patients to prevent chronically painful subluxation of the flaccid shoulder. Another involves strengthening the quadriceps muscles to protect an osteoarthritic knee from further stress and deterioration. Other applications in the planning phase include prevention of venous stasis and osteoporosis in patients with spinal cord injuries, reversal of equinus contractures of the ankle in cerebral palsy patients, and correction of footdrop in stroke patients. Still other clinical problems that may be candidates for such intramuscular stimulation include sleep apnea, disorders of gastrointestinal motility, and fecal and urinary incontinence. For most of these applications, clinical utility is as yet uncertain, morbidity would be unacceptable,...

The nutritional role of copper

Copper was identified as an essential trace element, first for animals1 and subsequently for humans2 when anaemia was successfully treated by supplementing the diet with a source of copper. Since then the full significance of its role in biological systems has continued to unfold as it has been identified in a large number of vital metalloproteins, as an allosteric component and as a cofactor for catalytic activity. These proteins perform numerous important roles in the body, relating to the maintenance of immune function, neural function, bone health, arterial compliance, haemostasis, and protection against oxidative and inflammatory damage. However, the accurate assessment of copper status is problematic. Functional copper status is the product of many interacting dietary and lifestyle factors, and an adequate marker of body copper status has yet to be identified. Accurate measurement of dietary copper intake is difficult because while a number of dietary factors are known to limit...

Definition of the Disease

Today, we recognize that osteoporosis occurs across all age groups and affects both genders. Osteoporosis is recognized as a disorder of bone remodeling that leads to deformations in the bone micro macroarchitecture, and a decrease in, or loss of, bone mass and density. With these events bone loses strength, becomes fragile, and as a consequence, is prone to fracture. Accelerated bone turnover is problematic because the bone formed is often of poor quality. Cortical bone becomes more porous. Trabeculae become thin, and gaps are often found between neighboring trabeculae where connections should be. As a result, bones become weak and less able to endure normal stresses. For many women, some, as yet undetermined, process causes the rate of turnover to slow down after about 5 years and bone continues to be lost but at a slower rate. For others, as in the case of our patient, bone turnover continues at an accelerated rate and leads to osteoporosis. Generally, estrogen deficiency is...

Treatment and Monitoring

Treating the patient diagnosed with osteoporosis takes a multipronged approach that includes an assessment of additional risk factors that the patient can control or modify. Unless the patient has a history of renal stones or hypercalcemia, one of the first steps is to encourage increased calcium and vitamin D intake through diet or supplementation. Habits that are known to correlate with increased bone loss, such as smoking or excessive alcohol consumption, are discouraged. Exercise, particularly weight-bearing exercise, improves bone density and is encouraged. One of the most important aspects of treatment is fracture prevention. By some estimates, osteoporosis leads to more than 1.5 million fractures annually, including 300,000 fractures of the hip, 250,000 of the wrist, and about 700,000 fractures of the vertebra. For many patients, a fracture is more than an inconvenience it is a serious, potentially life-threatening event. The risk of mortality following a fracture increases...

Additional Reading

The roles of bone mineral density, bone turnover, and other properties in reducing fracture risk during antiresorptive therapy. Mayo Clin Proc. 80 379-88, 2005. Fitzpatrick, L. A. Secondary causes of osteoporosis. Mayo Clin Proc. 77 453-68, 2002. Garnero, P., and Delmas, P. D. Contribution of bone mineral density and bone turnover markers to the in osteoporosis. Clin. Lab. Med. 24 175-97, 2004. Mahakala, A., Thoutreddy, S., and Kleerekoper, M. Prevention and treatment of postmenopausal osteoporosis. Treat. Endocrinol. 2 331-45, 2003.

Foundations for practical nutritional information

A number of health and disease end-points, affecting a large proportion of the population, need to be addressed in developing healthy foods. Some, such as cardiovascular disease, colorectal cancer, osteoporosis, and constipation are associated with a combination of ageing and unhealthy dietary patterns. Others, such as obesity, are largely the result of food processors and marketers successfully providing foods that appeal to the basic human preferences for sweetness and fats, in all age groups. It would be best to design foods with a number of endpoints in mind, and evaluate them with a battery of tests to demonstrate nutritional balance. Producing foods for specific functions or using foods as medicines risks unbalanced nutrient intake.

Gastrointestinal disease and nutrition

Gastrointestinal disease inevitably interferes with nutrition. Reduced intake may be due to nausea and vomiting, poor dentition, or dysphagia secondary to oesophageal disease. Pancreatic, biliary and intestinal diseases cause malabsorption. Coeliac disease and Crohn's disease in particular are associated with multiple deficiencies, including calcium and vitamin D deficiency leading to osteoporosis.

Regulation Of Osteoblast Apoptosis By

By caspase activation, DNA fragmentation, and condensation of the nucleus (35,36). Although Ker et al. formally proposed the concept of apoptosis in 1972, biologists have been aware that cell death occurs in bone since the early 1960s. Frost et al. described empty osteocyte lacunae in human bone specimens and suggested they were derived as a consequence of cell death (36-38). Emerging evidence indicates that apoptosis is an important component in skeletal development and remodeling. Well-coordinated homeostatic apoptosis of hypertropic chondrocytes in their terminal differentiation stage is essential for the progression of endochondral bone formation. Abnormal apoptosis of osteoblasts may be associated with bone disorders such as osteoporosis and Paget's disease of bone. It is widely accepted that once they have completed their bone-forming function, osteoblasts are either entrapped in bone matrix and become osteocytes or remain on the surfaces as lining cells. Studies since Frost's...

Treatment and Outcome

Prevention The most effective way to treat osteoporosis is to prevent it. Lifestyle changes that prevent osteoporosis are also helpful for treating it. Avoiding Causes of Osteoporosis People who have osteoporosis or want to prevent it should alter their lifestyle to avoid smoking and drinking a lot of alcohol since these decrease bone density. Avoiding drugs that cause osteoporosis is not always possible. For example, if someone needs high doses of corticosteroids to control an illness, then avoiding these drugs may not be possible. Most physicians agree that the lowest dose of corticosteroid that controls a condition should be used, and in this way the negative effects of this class of drugs on bone is kept to a minimum. Exercise Severe inactivity such as bed rest decreases bone density. This is because the stresses placed on bone by exercise help remodel and strengthen it. Weight-bearing exercise such as jogging, tennis, and weight lifting increases bone density. Exercise such as...

Acquired Hypercoagulable Disorders

Historically, hormone replacement therapy (HRT) has been used to reduce the progression of osteoporosis, relieve the symptoms of menopause, and reduce the cardiovascular risk profile. Several studies including the Heart Estrogen Progestin Replacement Study (HERS) and the Women's Health Initiative (WHI) have shown an increased risk of venous thromboembolism with the use of HRT. A two- to four-fold increased risk, compared to nonusers, has been shown.26,29

Caval Filter Insertion During Pregnancy

The choice of therapy for DVT of the lower extremity during pregnancy has been widely debated. Warfarin passes through the placenta to the fetus and may cause fetal complications and or death. Heparin, in contrast, does not cross the placenta, but its long-term use may be impractical and may increase the risk of bleeding, osteoporosis, and neurological complications.

Discovery and identification of Opgocif

OPG OCIF is a 401 amino acid protein with four cysteine-rich domains and two death domain homologous regions (Fig. 2). The death domain homologous regions share structural features with 'death domains' of TNF receptor p55, Fas and TRAIL receptors, which mediate apoptotic signals. OPG OCIF strongly inhibited osteoclast formation induced by either 1a,25(OH)2D3, PTH, prostaglandin E2 (PGE2) or IL-11 in mouse co-culture (Simonet et al 1997, Tsuda et al 1997, Yasuda et al 1998a). Analyses of transgenic mice expressing Opg Ocif and animals injected with OPG OCIF have demonstrated that this factor suppresses osteoclastic bone resorption, resulting in increased bone mass (Simonet et al 1997, Yasuda et al 1998a). In contrast, Opg Ocif knockout mice exhibited severe osteoporosis due to enhanced osteoclastogenesis (Bucay et al 1998, Mizuno et al 1998). These results suggest that OPG OCIF is a physiologically important inhibitor of osteoclastic bone resorption.

Bone Cell Response To Strain And Mechanical Forces

Estrogen receptors are likely to interact with mechanical strain and modify the skeletal response to mechanical unloading. This is supported by several studies. First, space flights result in greater bone loss induced by estrogen deficiency in ovariectomized rats (70). In addition, mechanical loading and estrogens in combination have more than additive effects on cell division and collagen synthesis in organ culture, showing interactions between strain and estrogen receptors (71). Moreover, strain activation of cell proliferation in rat osteoblastic cells is dependent on estrogen receptor (72). In rat osteoblasts, estrogen-related proliferation occurs through IGF-I receptor whereas mechanical strain stimulates cell proliferation through IGF-II production. In human osteoblasts, the proliferative response to strain and estrogens is mediated by the estrogen receptor and IGF-I signaling (73). Finally, mechanical strain activates estrogen response elements in bone cells transfected with...

Conclusions And Perspectives

The skeleton adapts to microgravity, unloading, and loading by changes in bone mass and architecture. Several changes in osteoblast and osteoclast recruitment and function and in bone formation and resorption in response to loading or unloading have been identified. The mechanisms by which mechanical strain may be transduced into cellular biochemical signals begin to be understood. It has been proposed that selected bone cells may respond to mechanical forces through multiple putative mechanoreceptors that are responsive to changes in the mechanical environment. Transduction of mechanical forces to biochemical signals may involve the coordination of multiple pathways, including integrins, cytoskeletal proteins, and activation of kinases, resulting in the release of signaling molecules, changes in cell proliferation, and gene expression in bone cells. Some key signaling molecules and transcription factors controlling bone cells in response to mechanical forces have been identified....

Clinical disorders of bone resorption

Clinical disorders in which bone resorption is increased are very common and include Paget's disease of bone, osteoporosis, and the bone changes secondary to cancer, such as occur in myeloma and metastases from breast cancer. Clinical disorders of reduced bone resorption are less common and often have a genetic basis, e.g. in osteopetrosis, and in pycnodysostosis due to cathepsin K deficiency. Bone is metabolically active throughout life. After skeletal growth is complete, remodelling of both cortical and trabecular bone continues and results in an annual turnover of about 10 of the adult skeleton. The commonest disorder of bone resorption is osteoporosis, which affects one in three women over 50 years. Its pathophysiological basis includes genetic predisposition and subtle alterations in systemic and local hormones, coupled with environmental influences. Treatment depends mainly on drugs that inhibit bone resorption, either directly or indirectly. This includes...

The major diseases of bone resorption

Osteoporosis affects 1 in 3 women over the age of 50 and leads to fractures, which cause significant suffering and disability. The cost to the NHS amounts to about 1 billion per annum. (A) Multiple mechanisms involved in the pathogenesis of osteoporosis. (B) X-rays of the commonest sites of fracture the wrist, spine and hip (left to right). FIG. 4. Osteoporosis affects 1 in 3 women over the age of 50 and leads to fractures, which cause significant suffering and disability. The cost to the NHS amounts to about 1 billion per annum. (A) Multiple mechanisms involved in the pathogenesis of osteoporosis. (B) X-rays of the commonest sites of fracture the wrist, spine and hip (left to right). TABLE 1 Current and future drugs for osteoporosis for osteoporosis (fluoride, anabolic steroids, testosterone in men, etc.) Osteoporosis. The past decade has witnessed a remarkably greater awareness of osteoporosis as a major health problem that is associated with profound socioeconomic...

Current therapy and drugs in development

TABLE 2 Some of the genes that may contribute to osteoporosis by influencing bone mass and rates of bone loss (Ralston 1997) FIG. 5. Chemical structures of drugs relevant to osteoporosis. The SERMs raloxifene, tamoxifen, and lasofoxiphene are shown alongside the natural oestrogen, oestradiol. The two bisphosphonates shown here are risedronate and ibandronate. FIG. 5. Chemical structures of drugs relevant to osteoporosis. The SERMs raloxifene, tamoxifen, and lasofoxiphene are shown alongside the natural oestrogen, oestradiol. The two bisphosphonates shown here are risedronate and ibandronate. inhalation. One of the more interesting recent achievements has been the development of more tissue-selective oestrogens or SERMs (selective oestrogen receptor modulators). The ideal compound of this type would possess all the good properties of oestrogens but none of the bad (MacGregor & Jordan 1998). Such an agent would therefore be effective in osteoporosis, ischaemic heart disease and...

Complications Of Heparin Therapy

The main adverse effects of heparin therapy include bleeding, thrombocytopenia, and osteoporosis. Patients at particular risk of bleeding are those who have had recent Osteoporosis has been reported in patients receiving unfractionated heparin in dosages of 20,000 U day (or more) for more than six months.12 Demineralization can progress to the fracture of vertebral bodies or long bones, and the defect may not be entirely reversible.12 Laboratory and clinical studies indicate that the incidence of osteoporosis with use of long-term LMWH is low.12 There has been a hope that the LMWHs will have fewer serious complications such as bleeding, heparin-induced thrombocytopenia and osteopenia, when compared with unfractionated heparin.45,47 Evidence is accumulating that these complications are indeed less serious and less frequent with the use of LMWH. LMWH has been approved for the prevention and treatment of venous thromboembolism in pregnancy. These drugs do not cross the placenta and large...

Vitamin K status and health 3211 Adults

Vitamin K deficiency in adults leading to clinical bleeding is almost unheard of, except as a consequence of hepato-intestinal disorders which disturb the absorption or utilisation of the vitamin. Use of warfarin or other anti-coagulant drugs, i.e. vitamin K antagonists, in the management of thromboembolic disease, reduces circulating concentrations of vitamin K-dependent clotting factors. The anticoagulants inhibit the biosynthesis of prothrombin and other vitamin K-dependent factors in the liver and others factors in extrahepatic tissues, leading to clotting factor deficiencies in the body (Olson, 1999). Studies investigating the effect of anticoagulants on bone health have shown mixed results but the participants were severely ill with chronic vascular disease which would have affected physical activity, a very important factor in bone health and may be the reason why vitamin K status did not appear to be important (Weber, 2001). 3.21.3 Bone health Despite gaps in knowledge it...

The Chromosomal House of Horrors

Another genetic disorder recently mapped to chromosome 8 causes individuals to senesce and die early, usually by age fifty. The gene responsible for Werner syndrome encodes a defective DNA helicase enzyme that in normal form appears to play a cellular role in the repair of DNA damages. The mutation leading to Werner syndrome has devastating effects patients in their thirties typically show pronounced symptoms of old age, such as cataracts, osteoporosis, and heart disease. The Werner syndrome gene provides an unusually clear example of direct genetic control over the aging phenomenon itself.

Mutations In The Gene That Encodes The Androgen Receptor

AIS females are often considered quite attractive by contemporary standards, and they are often taller than the average woman. The health implications of AIS are risk of testicular cancer, infertility, gonadectomy, hormone replacement therapy, and, eventually, osteoporosis. Psychologically, they are as stable and happy (or not) as women with two X chromosomes who end up coping with fertility issues. They can be expected to live perfectly happy, normal lives and, when they so choose, become parents of adopted children or stepchildren.

Other nutritional changes 1471 Antinutrients

Phytoestrogens in soy and other foods may protect post-menopausal women from osteoporosis and heart disease and protect men against prostate and other testosterone-dependent cancers. Extrusion can transform soy into food products with broad appeal for consumers, but processing effects on soy isoflavones and other phytoestrogens should be evaluated for any products for which health effects are intended. Blends of soy protein concentrate and cornmeal (20 80) were processed under different extrusion conditions (Mahungu et al, 1999). Increasing barrel temperature caused decarboxylation of isoflavones, with increased proportions of acetyl derivatives, but total isoflavones also decreased.

Weight Gain Infertility and Hypertension

Her past medical history was significant for a spontaneous rib fracture 12 months ago. She had reached for a book located on the floor and developed acute chest pain. Chest x-ray in the emergency department revealed the fracture. The fracture was treated conservatively with rest and external support. The radiology report noted some demineralization of the spine and ribs in addition to the fracture. Follow up bone mineral density (BMD) measurements via dexa scan revealed the following findings consistent with a decline in bone mineral density (SD standard deviation)

Middle Aged Woman with Colles Fracture

On physical examination, the patient is a 5-ft-tall, 94-lb middle-aged woman who describes herself as physically fit and in good health. She reports running 3-4 miles 3 times per week and participating in additional physical exercise that includes weight and resistance training. Her past medical history includes two full-term, uneventful pregnancies, menopause at age 41, but no history of thyroid disease, diabetes, or Cushing syndrome. A daily multivitamin supplement is her only current medication. She has never received hormone replacement therapy. She has no documented family history of osteoporosis, although she recalls her grandmother losing height as she aged and developing a dowager's hump, and notes that her 80-year-old mother appears to be losing height as well. The following laboratory results were obtained On the basis of the bone density report and the clinical laboratory data, a diagnosis of primary osteoporosis was made. The patient was counseled to continue her current...

A 46Year Old Female with a Painful Swollen Right Calf

A 46-year-old obese Caucasian woman presented to her general internist with recent onset of flushed skin and sweating. Over the previous 6 months she has noticed her hair thinning and complained of increasing irritability. She described occasional alcohol use and a 30-year history of 1 pack per day of tobacco use. The physician diagnosed early-onset menopause and discussed options for symptom management and prevention of osteoporosis. Conjugated estrogen therapy was initiated. Eight weeks later, the patient came to the emergency department with pain, redness, and swelling of the right calf. Venous Doppler studies confirmed deep venous thrombosis. Laboratory investigations characterized her coagulation status, and genetic tests for F5 (factor V) and F2 (prothrombin) mutations, associated with heritable predisposition to venous thrombosis, were performed

Molecular Regulation Of Osteoblast Differentiation By

To further study the role of Runx-2 in bone formation after birth, Ducy et al. (27) generated trans-genic mice that overexpressed a dominant-negative mutant of Runx-2 (DN-Runx-2) under the control of the osteocalcin promoter in differentiated osteoblasts. Mice expressing the DN-Cbfa1 presented a normal skeleton at birth but develop an osteopenic phenotype thereafter. Dynamic histomorphometric studies found that the osteopenia was caused by a major decrease in the bone formation rate, whereas the number of osteoblasts was normal. Molecular analyses revealed that the expression of the genes encoding bone extracellular matrix proteins was nearly abolished in these mice (27). These results indicate that Runx-2 also transcriptionally controls the function of mature osteoblasts. Conversely, Liu et al. (28) generated transgenic mice that overexpressed wild-type Runx-2 under the control of the type I collagen promoter in osteoblasts. Paradoxically, they found that Runx-2 transgenic mice also...

Hair loss

Children with anorexia also can develop osteoporosis, muscle loss and weakness, severe dehydration leading to kidney failure, fainting, fatigue, and overall weakness, hair loss, and growth of a downy layer of hair called lanugo all over the body, including the face. As the girl's weight plummets, vital organs such as the brain and heart can be damaged.


If the T3 and FT4 are both normal in the face of a persistent suppression in TSH not otherwise explained (e.g., dopamine or high-dose glucocorticoid use, pituitary or hypo-thalamic insufficiency), subclinical hyperthyroidism is diagnosed. Increased prevalence of atrial arrhythmias and osteoporosis have been observed in individuals with subclinical hyperthyroidism.


Isoflavones do appear to exert some health benefits. The majority of data available relate to their effects on menopausal symptoms. Consumption of as little as 30 mg of soy isoflavones, in soy protein or as an extract, reduces vasomotor menopausal symptoms by approximately 30 to 50 , including the placebo effect, or approximately 10 to 20 after subtracting the placebo effect. Soy protein and isoflavones work together to lower LDL cholesterol and increase HDL cholesterol. Benefits to bone health are less certain, although some data suggest that they may prevent bone loss over the short term. Effects on breast cancer risk are complex. Isoflavones are likely to be cancer preventive when consumed early in life, but a few animal studies that show stimulation of breast cancer cell growth raise sufficient concerns that phytoestrogen supplements should not be recommended for women at high risk of breast cancer.


Osteogenesis Imperfecta (OI) and Osteoporosis (Collagen I) Because OI is a highly heterogeneous disorder, it is in some cases difficult to distinguish patients with milder forms of OI from familial osteoporosis, which result in fractures (1). Therefore, type I collagen mutations have also been found in some patients who show little evidence of OI but have osteopenia and fractures (1,47). However, type I collagen mutations are not likely to be common causes of osteoporosis (1,47).


4.5.3 Osteoporosis Osteoporosis is a condition which is characterised by loss of bone tissue from the skeleton and deterioration of bone structure with enhanced bone fragility and increased risk of fracture. It is relatively common in the elderly, especially females, but may also occur in the young. In the UK one in three women and one in twelve men over the age of 50 years can expect to have an osteoporotic fracture during the remainder of their lives (Prentice, 2001). The causes of osteoporosis, in spite of extensive research, remain elusive. The higher rate in women seems to be associated with a number of factors the lower skeletal mass in women compared to men, a greater rate of calcium loss and a fall in oestrogen production with age. Lifetime history is also important. Higher intakes of calcium, especially in adolescence and early adulthood, ensure greater bone density. In addition, physical exercise can help increase calcium deposition, while high consumption of alcohol,...

Role of Bone Markers

Bone formation, and bone degradation products. Unfortunately, none is sufficiently specific to be diagnostic for osteoporosis. They do, however, have roles in the evaluation and treatment of these patients, especially in assessing fracture risk and in monitoring treatment. The analytes associated with bone resorption include urinary calcium, tartrate-resistant acid phosphatase, bone sialoprotein, type 1 collagen crosslinked telopep-tides, and pyridinium derivatives those reflecting bone formation include bone alkaline phosphatase, osteocalcin, and the type 1 collagen propeptides Osteocalcin. Both osteoblasts and otodontoblasts synthesize osteocalcin, but since osteoblasts greatly outnumber otodontoblasts, most of the protein in the circulation reflects osteoblast activity. The protein originates as a 75-amino-acid propeptide that is first carboxylated before further posttranslational processing. The degree of carboxylation determines the protein's affinity for calcium and...

Menopause 309

Estrogen replacement therapy is generally offered to menopausal women to reduce bothersome or debilitating symptoms (hot flashes, insomnia, decreased sexual functioning, decreased appetite, night sweats, weight loss, fatigue, vagini-tis, dysuria, etc.), to prevent demineralization of bones (leading to osteoporosis), and to offset changes in lipid metabolism related to heart disease. Estrogen is supplemented with progestin to offset the documented increase in endometrial cancer and potential increased risk of breast cancer

Computer Simulations

Several studies have used computer models to gain more insight in the relation between bone remodeling and changes in the skeleton with age, during menopause, or in osteoporosis. The first models of cancellous bone treated the cancellous bone as a number of bone packages (22) or used trabeculae with a certain thickness distribution derived from published histomorphometric data (23). In these models, the trabeculae were not connected to form a cancellous architecture.

Vitamin D And Bone

The relationship between vitamin D and bone is, among others, illustrated by the treatment of osteoporosis with vitamin D, which has been studied and discussed in various studies (1,2). In addition, a reduction of fracture risk by treatment with vitamin D has been reported (3-6). Last year, an overview of all randomized trials studying vitamin D treatment in elderly men or women with involutional or postmenopausal osteoporosis has been published (7). However, the effects on calcium and phosphate homeostasis make it difficult to identify whether vitamin D is directly involved in control of bone metabolism. The bone abnormalities in hypo- and hypervitamin D states mostly result of indirect effects because of changes in concentrations of serum calcium and phosphate. For example, studies

Treatment Approach

In meeting these goals, the advantages of increased tone must be considered. Spasticity can substitute for strength with direct improvements in walking, transfers, and assuming an upright posture. The intrinsic increase in muscle tone may also serve to reduce the risk of osteoporosis and decrease the risk of deep venous thrombosis and edema. Despite the advantages of spasticity, it is obvious that there is quite a bit of morbidity associated with the condition. Tension on the bones while minimizing osteoporosis may lead to orthopedic deformity, such as hip dislocation, scoliosis, and contracture. This may make mobility and activities of daily living more difficult. It may also result in skin breakdown as additional pressure is added to areas not accustomed to mechanical stress. Pain is often associated with spasticity and should always be a consideration in formulating a treatment plan for patients.

Copper deficiency

Symptoms usually appear within the first months of life, and can result in death in early childhood.31 In clinical copper deficiency, the most common defects are cardiovascular and haematological disorders including iron-resistant anaemia, neutropenia and thrombocytopenia bone abnormalities including osteoporosis and fractures and alterations to skin and hair texture and pigmentation.23 Immunological changes have also been indicated.19,32 These changes may be accompanied by depressed serum copper and blood cupro-enzymes, with caeruloplasmin concentrations observed at 30 of normal.6